Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia

Lewy body dementia is the second most common neurodegenerative dementia and is pathologically characterized by α-synuclein positive cytoplasmic inclusions, with varying amounts of amyloid-β (Aβ) and hyperphosphorylated tau (tau) aggregates in addition to synaptic loss. A dysfunctional ubiquitin prot...

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Detalles Bibliográficos
Autores principales: Alghamdi, Amani, Vallortigara, Julie, Howlett, David R., Broadstock, Martin, Hortobágyi, Tibor, Ballard, Clive, Thomas, Alan J., O’Brien, John T., Aarsland, Dag, Attems, Johannes, Francis, Paul T., Whitfield, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438478/
https://www.ncbi.nlm.nih.gov/pubmed/28269775
http://dx.doi.org/10.3233/JAD-160946

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