The chimeric monoclonal antibody MHCSZ-123 against human von Willebrand factor A3 domain inhibits high-shear arterial thrombosis in a Rhesus monkey model

BACKGROUND: SZ-123, a murine monoclonal antibody that targets the human von Willebrand factor (VWF) A3 domain and blocks the binding of collagen, is a powerful antithrombotic. In a Rhesus monkey model of thrombosis, SZ-123 had no side effects, such as bleeding or thrombocytopenia. METHODS: The mouse...

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Detalles Bibliográficos
Autores principales: Ji, Shundong, Jiang, Miao, Yan, Bin, Shen, Fei, He, Yang, Wan, Aini, Xia, Lijun, Ruan, Changgeng, Zhao, Yiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438484/
https://www.ncbi.nlm.nih.gov/pubmed/28526067
http://dx.doi.org/10.1186/s13045-017-0475-2

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