Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia

BACKGROUND: The CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL. Binding of the pro-survival chemokine CXCL12 with its cognate receptor CX...

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Detalles Bibliográficos
Autores principales: Kashyap, Manoj K., Amaya-Chanaga, Carlos I., Kumar, Deepak, Simmons, Brett, Huser, Nanni, Gu, Yin, Hallin, Max, Lindquist, Kevin, Yafawi, Rolla, Choi, Michael Y., Amine, Ale-Ali, Rassenti, Laura Z., Zhang, Cathy, Liu, Shu-Hui, Smeal, Tod, Fantin, Valeria R., Kipps, Thomas J., Pernasetti, Flavia, Castro, Januario E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438492/
https://www.ncbi.nlm.nih.gov/pubmed/28526063
http://dx.doi.org/10.1186/s13045-017-0435-x

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