Mitochondrial complex I deficiency leads to the retardation of early embryonic development in Ndufs4 knockout mice

BACKGROUND: The NDUFS4 gene encodes an 18-kD subunit of mitochondria complex I, and mutations in this gene lead to the development of a severe neurodegenerative disease called Leigh syndrome (LS) in humans. To investigate the disease phenotypes and molecular mechanisms of Leigh syndrome, the Ndufs4...

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Detalles Bibliográficos
Autores principales: Wang, Mei, Huang, Ya-Ping, Wu, Han, Song, Ke, Wan, Cong, Chi, A-Ni, Xiao, Ya-Mei, Zhao, Xiao-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2017
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438584/
https://www.ncbi.nlm.nih.gov/pubmed/28533980
http://dx.doi.org/10.7717/peerj.3339

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