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IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis

Accumulated data have shown that alternatively activated macrophage exerts a modulatory role in many diseases, including colitis. Interleukin-33 (IL-33), a critical modulator in adaptive and innate immune, has been implicated in autoimmunity and inflammation. Previously, we have reported that IL-33...

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Autores principales: Tu, Lei, Chen, Jie, Xu, Dandan, Xie, Zhongming, Yu, Bing, Tao, Ying, Shi, Guixiu, Duan, Lihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438602/
https://www.ncbi.nlm.nih.gov/pubmed/28423665
http://dx.doi.org/10.18632/oncotarget.15984
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author Tu, Lei
Chen, Jie
Xu, Dandan
Xie, Zhongming
Yu, Bing
Tao, Ying
Shi, Guixiu
Duan, Lihua
author_facet Tu, Lei
Chen, Jie
Xu, Dandan
Xie, Zhongming
Yu, Bing
Tao, Ying
Shi, Guixiu
Duan, Lihua
author_sort Tu, Lei
collection PubMed
description Accumulated data have shown that alternatively activated macrophage exerts a modulatory role in many diseases, including colitis. Interleukin-33 (IL-33), a critical modulator in adaptive and innate immune, has been implicated in autoimmunity and inflammation. Previously, we have reported that IL-33 functions as a protective modulator in TNBS-induced colitis, which is closely related to a Th1-to-Th2/Treg switch. Here, we present novel evidence suggesting that IL-33 primes macrophage into alternatively activated macrophages (AAM) in TNBS-induced colitis. The strong polarized effect of IL-33 was tightly associated with the markedly increased induction of Th2-type cytokines. To confirm the beneficial effects of AAM induced by IL-33, peritoneal AAMs isolated from IL-33-treated mice were transferred to recipient mice with TNBS colitis. The adoptive transfer resulted in prominent inhibition of disease activity and inflammatory cytokines in the TNBS-treated mice. In conclusion, our data provide clear evidence that IL-33 plays a protective role in TNBS-induced colitis, which is closely related to AAM polarization.
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spelling pubmed-54386022017-05-24 IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis Tu, Lei Chen, Jie Xu, Dandan Xie, Zhongming Yu, Bing Tao, Ying Shi, Guixiu Duan, Lihua Oncotarget Research Paper: Immunology Accumulated data have shown that alternatively activated macrophage exerts a modulatory role in many diseases, including colitis. Interleukin-33 (IL-33), a critical modulator in adaptive and innate immune, has been implicated in autoimmunity and inflammation. Previously, we have reported that IL-33 functions as a protective modulator in TNBS-induced colitis, which is closely related to a Th1-to-Th2/Treg switch. Here, we present novel evidence suggesting that IL-33 primes macrophage into alternatively activated macrophages (AAM) in TNBS-induced colitis. The strong polarized effect of IL-33 was tightly associated with the markedly increased induction of Th2-type cytokines. To confirm the beneficial effects of AAM induced by IL-33, peritoneal AAMs isolated from IL-33-treated mice were transferred to recipient mice with TNBS colitis. The adoptive transfer resulted in prominent inhibition of disease activity and inflammatory cytokines in the TNBS-treated mice. In conclusion, our data provide clear evidence that IL-33 plays a protective role in TNBS-induced colitis, which is closely related to AAM polarization. Impact Journals LLC 2017-03-07 /pmc/articles/PMC5438602/ /pubmed/28423665 http://dx.doi.org/10.18632/oncotarget.15984 Text en Copyright: © 2017 Tu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Immunology
Tu, Lei
Chen, Jie
Xu, Dandan
Xie, Zhongming
Yu, Bing
Tao, Ying
Shi, Guixiu
Duan, Lihua
IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis
title IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis
title_full IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis
title_fullStr IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis
title_full_unstemmed IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis
title_short IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis
title_sort il-33-induced alternatively activated macrophage attenuates the development of tnbs-induced colitis
topic Research Paper: Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438602/
https://www.ncbi.nlm.nih.gov/pubmed/28423665
http://dx.doi.org/10.18632/oncotarget.15984
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