Cargando…
Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease
Beneficial effects of the Chinese herbal medicine Qushi Huayu Decoction (QHD) were observed with non-alcoholic fatty liver disease (NAFLD) patients and animal models. The impact of QHD or its active components (geniposide and chlorogenic acid, GC) on NAFLD liver transcriptome and gut microbiota was...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438611/ https://www.ncbi.nlm.nih.gov/pubmed/28416740 http://dx.doi.org/10.18632/oncotarget.15482 |
_version_ | 1783237801362325504 |
---|---|
author | Feng, Qin Liu, Wensheng Baker, Susan S. Li, Hongshan Chen, Cheng Liu, Qian Tang, Shijie Guan, Lingyu Tsompana, Maria Kozielski, Rafal Baker, Robert D. Peng, Jinghua Liu, Ping Zhu, Ruixin Hu, Yiyang Zhu, Lixin |
author_facet | Feng, Qin Liu, Wensheng Baker, Susan S. Li, Hongshan Chen, Cheng Liu, Qian Tang, Shijie Guan, Lingyu Tsompana, Maria Kozielski, Rafal Baker, Robert D. Peng, Jinghua Liu, Ping Zhu, Ruixin Hu, Yiyang Zhu, Lixin |
author_sort | Feng, Qin |
collection | PubMed |
description | Beneficial effects of the Chinese herbal medicine Qushi Huayu Decoction (QHD) were observed with non-alcoholic fatty liver disease (NAFLD) patients and animal models. The impact of QHD or its active components (geniposide and chlorogenic acid, GC) on NAFLD liver transcriptome and gut microbiota was examined with NAFLD rats. Increased expression for genes required for glutathione production and decreased expression for genes required for lipid synthesis was observed in NAFLD livers treated with QHD and GC. GC treatment decreased serum LPS, which could be explained by reduced mucosal damage in the colon of GC-treated rats. Further, our data suggest an increased abundance of Treg-inducing bacteria that stimulated the Treg activity in GC treated colon, which in turn down-regulated inflammatory signals, improved gut barrier function and consequently reduced hepatic exposure to microbial products. Our study suggests that QHD simultaneously enhanced the hepatic anti-oxidative mechanism, decreased hepatic lipid synthesis, and promoted the regulatory T cell inducing microbiota in the gut. |
format | Online Article Text |
id | pubmed-5438611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54386112017-05-24 Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease Feng, Qin Liu, Wensheng Baker, Susan S. Li, Hongshan Chen, Cheng Liu, Qian Tang, Shijie Guan, Lingyu Tsompana, Maria Kozielski, Rafal Baker, Robert D. Peng, Jinghua Liu, Ping Zhu, Ruixin Hu, Yiyang Zhu, Lixin Oncotarget Research Paper Beneficial effects of the Chinese herbal medicine Qushi Huayu Decoction (QHD) were observed with non-alcoholic fatty liver disease (NAFLD) patients and animal models. The impact of QHD or its active components (geniposide and chlorogenic acid, GC) on NAFLD liver transcriptome and gut microbiota was examined with NAFLD rats. Increased expression for genes required for glutathione production and decreased expression for genes required for lipid synthesis was observed in NAFLD livers treated with QHD and GC. GC treatment decreased serum LPS, which could be explained by reduced mucosal damage in the colon of GC-treated rats. Further, our data suggest an increased abundance of Treg-inducing bacteria that stimulated the Treg activity in GC treated colon, which in turn down-regulated inflammatory signals, improved gut barrier function and consequently reduced hepatic exposure to microbial products. Our study suggests that QHD simultaneously enhanced the hepatic anti-oxidative mechanism, decreased hepatic lipid synthesis, and promoted the regulatory T cell inducing microbiota in the gut. Impact Journals LLC 2017-02-18 /pmc/articles/PMC5438611/ /pubmed/28416740 http://dx.doi.org/10.18632/oncotarget.15482 Text en Copyright: © 2017 Feng et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Feng, Qin Liu, Wensheng Baker, Susan S. Li, Hongshan Chen, Cheng Liu, Qian Tang, Shijie Guan, Lingyu Tsompana, Maria Kozielski, Rafal Baker, Robert D. Peng, Jinghua Liu, Ping Zhu, Ruixin Hu, Yiyang Zhu, Lixin Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease |
title | Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease |
title_full | Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease |
title_fullStr | Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease |
title_full_unstemmed | Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease |
title_short | Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease |
title_sort | multi-targeting therapeutic mechanisms of the chinese herbal medicine qhd in the treatment of non-alcoholic fatty liver disease |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438611/ https://www.ncbi.nlm.nih.gov/pubmed/28416740 http://dx.doi.org/10.18632/oncotarget.15482 |
work_keys_str_mv | AT fengqin multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT liuwensheng multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT bakersusans multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT lihongshan multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT chencheng multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT liuqian multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT tangshijie multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT guanlingyu multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT tsompanamaria multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT kozielskirafal multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT bakerrobertd multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT pengjinghua multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT liuping multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT zhuruixin multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT huyiyang multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease AT zhulixin multitargetingtherapeuticmechanismsofthechineseherbalmedicineqhdinthetreatmentofnonalcoholicfattyliverdisease |