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Clinical implications of genomic profiles in metastatic breast cancer with a focus on TP53 and PIK3CA, the most frequently mutated genes

Breast cancer (BC) has been genetically profiled through large-scale genome analyses. However, the role and clinical implications of genetic alterations in metastatic BC (MBC) have not been evaluated. Therefore, we conducted whole-exome sequencing (WES) and RNA-Seq of 37 MBC samples and targeted dee...

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Detalles Bibliográficos
Autores principales:	Kim, Ji-Yeon, Lee, Eunjin, Park, Kyunghee, Park, Woong-Yang, Jung, Hae Hyun, Ahn, Jin Seok, Im, Young-Hyuck, Park, Yeon Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438625/ https://www.ncbi.nlm.nih.gov/pubmed/28427202 http://dx.doi.org/10.18632/oncotarget.15881

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