An extensive molecular cytogenetic characterization in high-risk chronic lymphocytic leukemia identifies karyotype aberrations and TP53 disruption as predictors of outcome and chemorefractoriness

We investigated whether karyotype analysis and mutational screening by next generation sequencing could predict outcome in 101 newly diagnosed chronic lymphocytic leukemia patients with high-risk features, as defined by the presence of unmutated IGHV gene and/or 11q22/17p13 deletion by FISH and/or T...

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Detalles Bibliográficos
Autores principales: Rigolin, Gian Matteo, Formigaro, Luca, Cavallari, Maurizio, Quaglia, Francesca Maria, Lista, Enrico, Urso, Antonio, Guardalben, Emanuele, Martinelli, Sara, Saccenti, Elena, Bassi, Cristian, Lupini, Laura, Bardi, Maria Antonella, Volta, Eleonora, Tammiso, Elisa, Melandri, Aurora, Negrini, Massimo, Cavazzini, Francesco, Cuneo, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438626/
https://www.ncbi.nlm.nih.gov/pubmed/28427204
http://dx.doi.org/10.18632/oncotarget.15883

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