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Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia

BACKGROUND: Poly-(ADP-ribose)-polymerase1 (PARP1) is involved in repair of DNA single strand breaks. PARP1-inhibitors (PARP1-i) cause an accumulation of DNA double strand breaks, which are generally repaired by homologous recombination (HR). Therefore, cancer cells harboring HR deficiencies are exce...

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Detalles Bibliográficos
Autores principales:	Oei, Arlene L., van Leeuwen, Caspar M., Ahire, Vidhula R., Rodermond, Hans M., Cate, Rosemarie ten, Westermann, Anneke M., Stalpers, Lukas J.A., Crezee, Johannes, Petra Kok, H., Krawczyk, Przemek M., Kanaar, Roland, Franken, Nicolaas A.P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438635/ https://www.ncbi.nlm.nih.gov/pubmed/28427225 http://dx.doi.org/10.18632/oncotarget.15922

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