HDAC8 overexpression in mesenchymal stromal cells from JAK2(+) myeloproliferative neoplasms: a new therapeutic target?

Histone deacetylases (HDACs) are involved in epigenetic modulation and their aberrant expression has been demonstrated in myeloproliferative neoplasms (MPN). HDAC8 inhibition has been shown to inhibit JAK2/STAT5 signaling in hematopoietic cells from MPN. Nevertheless, the role of HDAC8 expression in...

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Detalles Bibliográficos
Autores principales: Ramos, Teresa L., Sánchez-Abarca, Luis Ignacio, Redondo, Alba, Hernández-Hernández, Ángel, Almeida, Antonio M., Puig, Noemí, Rodríguez, Concepción, Ortega, Rebeca, Preciado, Silvia, Rico, Ana, Muntión, Sandra, González Porras, José Ramón, Cañizo, Consuelo Del, Sánchez-Guijo, Fermín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438642/
https://www.ncbi.nlm.nih.gov/pubmed/28390197
http://dx.doi.org/10.18632/oncotarget.15969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438642/
https://www.ncbi.nlm.nih.gov/pubmed/28390197
http://dx.doi.org/10.18632/oncotarget.15969

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