Cargando…

Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells

The current study tested the anti-hepatocellular carcinoma (HCC) cell activity of TIC10, a first-in-class small-molecule tumor necrosis (TNF)-related apoptosis-inducing ligand (TRAIL) inducer. TIC10 exerted potent anti-proliferative and pro-apoptotic actions in primary and established human HCC cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Long, Liu, Yuan-yuan, Lu, Pei-Hua, Peng, Yi, Yuan, Qiang, Gu, Xin-shi, Jin, Yong, Chen, Min-Bin, Bai, Xu-ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438657/ https://www.ncbi.nlm.nih.gov/pubmed/28415690 http://dx.doi.org/10.18632/oncotarget.16073

Ejemplares similares

KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms
por: Chen, Min-Bin, et al.
Publicado: (2016)

Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells
por: Zhen, Yun-fang, et al.
Publicado: (2016)

Genome-wide identification of DNA-PKcs-associated RNAs by RIP-Seq
por: Song, Zhiquan, et al.
Publicado: (2019)

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ
por: Chen, Siyu, et al.
Publicado: (2023)

DNA-PKcs: A Multi-Faceted Player in DNA Damage Response
por: Yue, Xiaoqiao, et al.
Publicado: (2020)

HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response
por: Guo, Zongpei, et al.
Publicado: (2020)

DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response
por: Han, Yang, et al.
Publicado: (2019)

Unraveling the roles of WRN and DNA-PKcs at telomeres
por: Beattie, Tara L., et al.
Publicado: (2010)

DNA-PKcs participated in hypoxic pulmonary hypertension
por: Liu, Ying-ying, et al.
Publicado: (2022)

Lost in the bloom: DNA-PKcs in green plants
por: Kumar, Koppolu Raja Rajesh
Publicado: (2023)

Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation
por: Yan, Dan, et al.
Publicado: (2010)

PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis
por: Li, Bing, et al.
Publicado: (2013)

DNA structure-specific priming of ATR activation by DNA-PKcs
por: Vidal-Eychenié, Sophie, et al.
Publicado: (2013)

DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy
por: Geng, Wei, et al.
Publicado: (2019)

Targeting DNA-PKcs and telomerase in brain tumour cells
por: Gurung, Resham Lal, et al.
Publicado: (2014)

DNA-PKcs: A Targetable Protumorigenic Protein Kinase
por: Dylgjeri, Emanuela, et al.
Publicado: (2022)

Identification of Key Phospholipids That Bind and Activate Atypical PKCs
por: Velnati, Suresh, et al.
Publicado: (2021)

LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma
por: Guo, Zhen, et al.
Publicado: (2021)

Beyond DNA Repair: DNA-PKcs in Tumor Metastasis, Metabolism and Immunity
por: Yang, Haitang, et al.
Publicado: (2020)

Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs
por: Liang, Shikang, et al.
Publicado: (2022)

Identification of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) as a Novel Target of Bisphenol A
por: Ito, Yuki, et al.
Publicado: (2012)

Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs
por: Bosch-Guiteras, Núria, et al.
Publicado: (2021)

Structural analysis of the basal state of the Artemis:DNA-PKcs complex
por: Watanabe, Go, et al.
Publicado: (2022)

Dual inhibition of DNA-PKcs and mTOR by CC-115 potently inhibits human renal cell carcinoma cell growth
por: Zheng, Bing, et al.
Publicado: (2020)

The leucine rich region of DNA-PKcs contributes to its innate DNA affinity
por: Gupta, Shikha, et al.
Publicado: (2005)

Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells
por: Lu, Pei-Hua, et al.
Publicado: (2017)

SENP3‐mediated TIP60 deSUMOylation is required for DNA‐PKcs activity and DNA damage repair
por: Han, Yang, et al.
Publicado: (2022)

Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity
por: Tsai, Chiao-Ling, et al.
Publicado: (2023)

Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination
por: Zhang, Shi-Meng, et al.
Publicado: (2014)

Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops
por: Kusumoto-Matsuo, Rika, et al.
Publicado: (2010)

Assessment of DNA-PKcs kinase activity by quantum dot–based microarray
por: Lafont, Florian, et al.
Publicado: (2018)

DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes
por: Kim Wiese, Ara, et al.
Publicado: (2017)

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex
por: Chang, Howard H.Y., et al.
Publicado: (2016)

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
por: Zhang, Shichuan, et al.
Publicado: (2011)

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
por: Caron, Pierre, et al.
Publicado: (2015)

LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer
por: Wang, You-hong, et al.
Publicado: (2021)

Mind the Difference Between Primary Tics and Functional Tic‐like Behaviors
por: Müller‐Vahl, Kirsten R., et al.
Publicado: (2021)

Black Phosphorus Quantum Dots Enhance the Radiosensitivity of Human Renal Cell Carcinoma Cells through Inhibition of DNA-PKcs Kinase
por: Lang, Yue, et al.
Publicado: (2022)

ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions
por: Soni, Aashish, et al.
Publicado: (2022)

PKCs pick through Ca(2+)
por: LeBrasseur, Nicole
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_s4mmqfp9so8j2b2vui5nt2fttm