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TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population
Single nucleotide polymorphisms (SNPs) in TCF7L2 (Transcription Factor 7-Like 2) reportedly affect susceptibility to schizophrenia (SCZ). We examined the association between TCF7L2 polymorphisms and SCZ susceptibility in a Chinese Han population. Six SNPs were genotyped in 499 SCZ patients and 500 h...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438676/ https://www.ncbi.nlm.nih.gov/pubmed/28404897 http://dx.doi.org/10.18632/oncotarget.15603 |
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author | Liu, Lijun Li, Jingjie Yan, Mengdan Li, Jing Chen, Junyu Zhang, Yi Zhu, Xikai Wang, Li Kang, Longli Yuan, Dongya Jin, Tianbo |
author_facet | Liu, Lijun Li, Jingjie Yan, Mengdan Li, Jing Chen, Junyu Zhang, Yi Zhu, Xikai Wang, Li Kang, Longli Yuan, Dongya Jin, Tianbo |
author_sort | Liu, Lijun |
collection | PubMed |
description | Single nucleotide polymorphisms (SNPs) in TCF7L2 (Transcription Factor 7-Like 2) reportedly affect susceptibility to schizophrenia (SCZ). We examined the association between TCF7L2 polymorphisms and SCZ susceptibility in a Chinese Han population. Six SNPs were genotyped in 499 SCZ patients and 500 healthy individuals, after which their associations with SCZ were evaluated using the Chi-squared test and genetic model analyses. We observed that the allele A of rs12573128 is associated with an increased SCZ risk (odds ratio [OR] = 1.33, 95% confidence interval [CI]: 1.08-1.63, P = 0.006, adjusted P = 0.030). The AA genotype of rs12573128 was associated with a higher SCZ risk than the GG genotype, before and after adjustment for sex and age (adjusted OR = 2.97, 95% CI: 1.49-5.92, P = 0.002). In addition, SNP rs12573128 was associated with 1.47-fold, 2.64-fold and 1.50-fold increases in SCZ risk of in dominant, recessive and additive model, respectively (adjusted OR = 1.47, 95% CI = 1.09-1.99, P = 0.012; Bonferroni adjusted P = 0.030). adjusted OR = 2.64, 95% CI = 1.34-5.18, P = 0.005 and adjusted OR = 1.50, 95% CI = 1.17-1.93, P = 0.002, respectively). These results suggest rs12573128 is significantly associated with an increased risk of SCZ in the Chinese Han population. |
format | Online Article Text |
id | pubmed-5438676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54386762017-05-24 TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population Liu, Lijun Li, Jingjie Yan, Mengdan Li, Jing Chen, Junyu Zhang, Yi Zhu, Xikai Wang, Li Kang, Longli Yuan, Dongya Jin, Tianbo Oncotarget Research Paper Single nucleotide polymorphisms (SNPs) in TCF7L2 (Transcription Factor 7-Like 2) reportedly affect susceptibility to schizophrenia (SCZ). We examined the association between TCF7L2 polymorphisms and SCZ susceptibility in a Chinese Han population. Six SNPs were genotyped in 499 SCZ patients and 500 healthy individuals, after which their associations with SCZ were evaluated using the Chi-squared test and genetic model analyses. We observed that the allele A of rs12573128 is associated with an increased SCZ risk (odds ratio [OR] = 1.33, 95% confidence interval [CI]: 1.08-1.63, P = 0.006, adjusted P = 0.030). The AA genotype of rs12573128 was associated with a higher SCZ risk than the GG genotype, before and after adjustment for sex and age (adjusted OR = 2.97, 95% CI: 1.49-5.92, P = 0.002). In addition, SNP rs12573128 was associated with 1.47-fold, 2.64-fold and 1.50-fold increases in SCZ risk of in dominant, recessive and additive model, respectively (adjusted OR = 1.47, 95% CI = 1.09-1.99, P = 0.012; Bonferroni adjusted P = 0.030). adjusted OR = 2.64, 95% CI = 1.34-5.18, P = 0.005 and adjusted OR = 1.50, 95% CI = 1.17-1.93, P = 0.002, respectively). These results suggest rs12573128 is significantly associated with an increased risk of SCZ in the Chinese Han population. Impact Journals LLC 2017-02-22 /pmc/articles/PMC5438676/ /pubmed/28404897 http://dx.doi.org/10.18632/oncotarget.15603 Text en Copyright: © 2017 Liu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Liu, Lijun Li, Jingjie Yan, Mengdan Li, Jing Chen, Junyu Zhang, Yi Zhu, Xikai Wang, Li Kang, Longli Yuan, Dongya Jin, Tianbo TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population |
title | TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population |
title_full | TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population |
title_fullStr | TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population |
title_full_unstemmed | TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population |
title_short | TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population |
title_sort | tcf7l2 polymorphisms and the risk of schizophrenia in the chinese han population |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438676/ https://www.ncbi.nlm.nih.gov/pubmed/28404897 http://dx.doi.org/10.18632/oncotarget.15603 |
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