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Circulating miR-31 as an effective biomarker for detection and prognosis of human cancer: a meta-analysis
PURPOSE: Circulating miR-31 was found to be associated with cancers detection and prognosis. The present meta-analysis aimed to explore the effect of circulating miR-31 on cancer detection and prognosis. METHOD: The studies were accessed using multiple databases. RevMan5.3, Meta-DiSc 1.4, and STATA1...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438681/ https://www.ncbi.nlm.nih.gov/pubmed/28404921 http://dx.doi.org/10.18632/oncotarget.15638 |
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author | Ma, Yingjun Chen, Yunfang Lin, Jinbo Liu, Yi Luo, Kai Cao, Yong Wang, Tieqiang Jin, Hongwei Su, Zhan Wu, Haolin Chen, Xiaoliang Cheng, Jinquan |
author_facet | Ma, Yingjun Chen, Yunfang Lin, Jinbo Liu, Yi Luo, Kai Cao, Yong Wang, Tieqiang Jin, Hongwei Su, Zhan Wu, Haolin Chen, Xiaoliang Cheng, Jinquan |
author_sort | Ma, Yingjun |
collection | PubMed |
description | PURPOSE: Circulating miR-31 was found to be associated with cancers detection and prognosis. The present meta-analysis aimed to explore the effect of circulating miR-31 on cancer detection and prognosis. METHOD: The studies were accessed using multiple databases. RevMan5.3, Meta-DiSc 1.4, and STATA14.0 were used to estimate the pooled effects, heterogeneity among studies, and publication bias. RESULTS: A total of 14 studies with 1397 cancer patients and 1039 controls were included. For the 12 prognostic tests, the adjusted pooled-AUC was 0.79 (95% CI: 0.73-0.86) as the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odd ratio (DOR) from 10 tests was 0.79 (95% CI: 0.76-0.82), 0.79 (95% CI: 0.76-0.82), 3.81 (95% CI: 2.90-5.01), 0.26 (95% CI: 0.20-0.35), and 16.81 (95% CI: 9.67-29.25), respectively. For the 5 prognosis analyses, the pooled HR (hazard ratio) of overall survival (OS) was 1.55 (95% CI 1.30-1.86) for high versus low circulating miR-31 expression. However, high expression of circulating miR-31 did not significantly increase the risk of poor differentiation (pooled OR=1.39, 95% CI: 0.56-3.47) and LNM (pooled OR=3.46, 95% CI: 0.96-12.42) in lung cancer. CONCLUSION: Circulating miR-31 is an effective biomarker and could be used as a component of miRs signature for cancer detection and prognosis surveillance. |
format | Online Article Text |
id | pubmed-5438681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54386812017-05-24 Circulating miR-31 as an effective biomarker for detection and prognosis of human cancer: a meta-analysis Ma, Yingjun Chen, Yunfang Lin, Jinbo Liu, Yi Luo, Kai Cao, Yong Wang, Tieqiang Jin, Hongwei Su, Zhan Wu, Haolin Chen, Xiaoliang Cheng, Jinquan Oncotarget Research Paper PURPOSE: Circulating miR-31 was found to be associated with cancers detection and prognosis. The present meta-analysis aimed to explore the effect of circulating miR-31 on cancer detection and prognosis. METHOD: The studies were accessed using multiple databases. RevMan5.3, Meta-DiSc 1.4, and STATA14.0 were used to estimate the pooled effects, heterogeneity among studies, and publication bias. RESULTS: A total of 14 studies with 1397 cancer patients and 1039 controls were included. For the 12 prognostic tests, the adjusted pooled-AUC was 0.79 (95% CI: 0.73-0.86) as the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odd ratio (DOR) from 10 tests was 0.79 (95% CI: 0.76-0.82), 0.79 (95% CI: 0.76-0.82), 3.81 (95% CI: 2.90-5.01), 0.26 (95% CI: 0.20-0.35), and 16.81 (95% CI: 9.67-29.25), respectively. For the 5 prognosis analyses, the pooled HR (hazard ratio) of overall survival (OS) was 1.55 (95% CI 1.30-1.86) for high versus low circulating miR-31 expression. However, high expression of circulating miR-31 did not significantly increase the risk of poor differentiation (pooled OR=1.39, 95% CI: 0.56-3.47) and LNM (pooled OR=3.46, 95% CI: 0.96-12.42) in lung cancer. CONCLUSION: Circulating miR-31 is an effective biomarker and could be used as a component of miRs signature for cancer detection and prognosis surveillance. Impact Journals LLC 2017-02-23 /pmc/articles/PMC5438681/ /pubmed/28404921 http://dx.doi.org/10.18632/oncotarget.15638 Text en Copyright: © 2017 Ma et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Ma, Yingjun Chen, Yunfang Lin, Jinbo Liu, Yi Luo, Kai Cao, Yong Wang, Tieqiang Jin, Hongwei Su, Zhan Wu, Haolin Chen, Xiaoliang Cheng, Jinquan Circulating miR-31 as an effective biomarker for detection and prognosis of human cancer: a meta-analysis |
title | Circulating miR-31 as an effective biomarker for detection and prognosis of human cancer: a meta-analysis |
title_full | Circulating miR-31 as an effective biomarker for detection and prognosis of human cancer: a meta-analysis |
title_fullStr | Circulating miR-31 as an effective biomarker for detection and prognosis of human cancer: a meta-analysis |
title_full_unstemmed | Circulating miR-31 as an effective biomarker for detection and prognosis of human cancer: a meta-analysis |
title_short | Circulating miR-31 as an effective biomarker for detection and prognosis of human cancer: a meta-analysis |
title_sort | circulating mir-31 as an effective biomarker for detection and prognosis of human cancer: a meta-analysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438681/ https://www.ncbi.nlm.nih.gov/pubmed/28404921 http://dx.doi.org/10.18632/oncotarget.15638 |
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