Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors

Mutations in succinate dehydrogenase B (SDHB) gene are frequently observed in several tumors and associated with poor prognosis in these tumors. Therefore, drugs effective for SDHB-deficient tumors could fulfill an unmet medical need. In addition, such drugs would have an advantage in that selection...

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Detalles Bibliográficos
Autores principales: Kitazawa, Satoshi, Ebara, Shunsuke, Ando, Ayumi, Baba, Yuji, Satomi, Yoshinori, Soga, Tomoyoshi, Hara, Takahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438703/
https://www.ncbi.nlm.nih.gov/pubmed/28423651
http://dx.doi.org/10.18632/oncotarget.15959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438703/
https://www.ncbi.nlm.nih.gov/pubmed/28423651
http://dx.doi.org/10.18632/oncotarget.15959

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