Cargando…

Prognostic values of clinicopathological characteristics and survival outcomes in prostate infiltrating ductal carcinoma: a population-based study

Infiltrating ductal carcinoma (IDC) is a rare histologic subtype of prostate cancer. We investigated the clinicopathological features and prognosis of IDC compared with acinar cell carcinoma (ACC). We identified 3814 men diagnosed with prostate cancer between 2004 to and 2013 in the Surveillance, Ep...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yu-Peng, Chen, Shao-Hao, Wang, Shi-Tao, Li, Xiao-Dong, Cai, Hai, Lin, Yun-Zhi, Xue, Xue-Yi, Wei, Yong, Zheng, Qing-Shui, Xu, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438711/
https://www.ncbi.nlm.nih.gov/pubmed/28423709
http://dx.doi.org/10.18632/oncotarget.16070
_version_ 1783237826769321984
author Wu, Yu-Peng
Chen, Shao-Hao
Wang, Shi-Tao
Li, Xiao-Dong
Cai, Hai
Lin, Yun-Zhi
Xue, Xue-Yi
Wei, Yong
Zheng, Qing-Shui
Xu, Ning
author_facet Wu, Yu-Peng
Chen, Shao-Hao
Wang, Shi-Tao
Li, Xiao-Dong
Cai, Hai
Lin, Yun-Zhi
Xue, Xue-Yi
Wei, Yong
Zheng, Qing-Shui
Xu, Ning
author_sort Wu, Yu-Peng
collection PubMed
description Infiltrating ductal carcinoma (IDC) is a rare histologic subtype of prostate cancer. We investigated the clinicopathological features and prognosis of IDC compared with acinar cell carcinoma (ACC). We identified 3814 men diagnosed with prostate cancer between 2004 to and 2013 in the Surveillance, Epidemiology, and End Results database, including 511 IDC and 3303 ACC cases. Prostate cancer-specific survival (PCSS) was compared using univariate and multivariate Cox proportional hazards models. Generally, IDC occurred in older men (≥ 65 years old) and presented with larger sizes, and higher grades, American Joint Committee on Cancer (AJCC) stages, AJCC T stages, lymph node positive rates and metastasis rates. Men with IDC were less likely to undergo radical prostatectomy, but more likely to be treated with adjuvant radiation than men with ACC. Five-year PCSS rates were significantly worse in IDC. In the multivariate analysis, patients with ACC had a better PCSS than patients with IDC. In conclusion, IDC has unique clinicopathological characteristics and has worse prognosis than ACC. Multivariable Cox regression analysis showed that age over 85 years, higher grade and T stage, and metastasis at diagnosis were independent prognostic factors of worse survival outcomes, whereas radical prostatectomy was an independent prognostic factor of better survival outcomes.
format Online
Article
Text
id pubmed-5438711
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-54387112017-05-24 Prognostic values of clinicopathological characteristics and survival outcomes in prostate infiltrating ductal carcinoma: a population-based study Wu, Yu-Peng Chen, Shao-Hao Wang, Shi-Tao Li, Xiao-Dong Cai, Hai Lin, Yun-Zhi Xue, Xue-Yi Wei, Yong Zheng, Qing-Shui Xu, Ning Oncotarget Research Paper Infiltrating ductal carcinoma (IDC) is a rare histologic subtype of prostate cancer. We investigated the clinicopathological features and prognosis of IDC compared with acinar cell carcinoma (ACC). We identified 3814 men diagnosed with prostate cancer between 2004 to and 2013 in the Surveillance, Epidemiology, and End Results database, including 511 IDC and 3303 ACC cases. Prostate cancer-specific survival (PCSS) was compared using univariate and multivariate Cox proportional hazards models. Generally, IDC occurred in older men (≥ 65 years old) and presented with larger sizes, and higher grades, American Joint Committee on Cancer (AJCC) stages, AJCC T stages, lymph node positive rates and metastasis rates. Men with IDC were less likely to undergo radical prostatectomy, but more likely to be treated with adjuvant radiation than men with ACC. Five-year PCSS rates were significantly worse in IDC. In the multivariate analysis, patients with ACC had a better PCSS than patients with IDC. In conclusion, IDC has unique clinicopathological characteristics and has worse prognosis than ACC. Multivariable Cox regression analysis showed that age over 85 years, higher grade and T stage, and metastasis at diagnosis were independent prognostic factors of worse survival outcomes, whereas radical prostatectomy was an independent prognostic factor of better survival outcomes. Impact Journals LLC 2017-03-10 /pmc/articles/PMC5438711/ /pubmed/28423709 http://dx.doi.org/10.18632/oncotarget.16070 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wu, Yu-Peng
Chen, Shao-Hao
Wang, Shi-Tao
Li, Xiao-Dong
Cai, Hai
Lin, Yun-Zhi
Xue, Xue-Yi
Wei, Yong
Zheng, Qing-Shui
Xu, Ning
Prognostic values of clinicopathological characteristics and survival outcomes in prostate infiltrating ductal carcinoma: a population-based study
title Prognostic values of clinicopathological characteristics and survival outcomes in prostate infiltrating ductal carcinoma: a population-based study
title_full Prognostic values of clinicopathological characteristics and survival outcomes in prostate infiltrating ductal carcinoma: a population-based study
title_fullStr Prognostic values of clinicopathological characteristics and survival outcomes in prostate infiltrating ductal carcinoma: a population-based study
title_full_unstemmed Prognostic values of clinicopathological characteristics and survival outcomes in prostate infiltrating ductal carcinoma: a population-based study
title_short Prognostic values of clinicopathological characteristics and survival outcomes in prostate infiltrating ductal carcinoma: a population-based study
title_sort prognostic values of clinicopathological characteristics and survival outcomes in prostate infiltrating ductal carcinoma: a population-based study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438711/
https://www.ncbi.nlm.nih.gov/pubmed/28423709
http://dx.doi.org/10.18632/oncotarget.16070
work_keys_str_mv AT wuyupeng prognosticvaluesofclinicopathologicalcharacteristicsandsurvivaloutcomesinprostateinfiltratingductalcarcinomaapopulationbasedstudy
AT chenshaohao prognosticvaluesofclinicopathologicalcharacteristicsandsurvivaloutcomesinprostateinfiltratingductalcarcinomaapopulationbasedstudy
AT wangshitao prognosticvaluesofclinicopathologicalcharacteristicsandsurvivaloutcomesinprostateinfiltratingductalcarcinomaapopulationbasedstudy
AT lixiaodong prognosticvaluesofclinicopathologicalcharacteristicsandsurvivaloutcomesinprostateinfiltratingductalcarcinomaapopulationbasedstudy
AT caihai prognosticvaluesofclinicopathologicalcharacteristicsandsurvivaloutcomesinprostateinfiltratingductalcarcinomaapopulationbasedstudy
AT linyunzhi prognosticvaluesofclinicopathologicalcharacteristicsandsurvivaloutcomesinprostateinfiltratingductalcarcinomaapopulationbasedstudy
AT xuexueyi prognosticvaluesofclinicopathologicalcharacteristicsandsurvivaloutcomesinprostateinfiltratingductalcarcinomaapopulationbasedstudy
AT weiyong prognosticvaluesofclinicopathologicalcharacteristicsandsurvivaloutcomesinprostateinfiltratingductalcarcinomaapopulationbasedstudy
AT zhengqingshui prognosticvaluesofclinicopathologicalcharacteristicsandsurvivaloutcomesinprostateinfiltratingductalcarcinomaapopulationbasedstudy
AT xuning prognosticvaluesofclinicopathologicalcharacteristicsandsurvivaloutcomesinprostateinfiltratingductalcarcinomaapopulationbasedstudy