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Fatty acid metabolism in breast cancer subtypes

Dysregulation of fatty acid metabolism is recognized as a component of malignant transformation in many different cancers, including breast; yet the potential for targeting this pathway for prevention and/or treatment of cancer remains unrealized. Evidence indicates that proteins involved in both sy...

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Autor principal: Monaco, Marie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438746/
https://www.ncbi.nlm.nih.gov/pubmed/28412757
http://dx.doi.org/10.18632/oncotarget.15494
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author Monaco, Marie E.
author_facet Monaco, Marie E.
author_sort Monaco, Marie E.
collection PubMed
description Dysregulation of fatty acid metabolism is recognized as a component of malignant transformation in many different cancers, including breast; yet the potential for targeting this pathway for prevention and/or treatment of cancer remains unrealized. Evidence indicates that proteins involved in both synthesis and oxidation of fatty acids play a pivotal role in the proliferation, migration and invasion of breast cancer cells. The following essay summarizes data implicating specific fatty acid metabolic enzymes in the genesis and progression of breast cancer, and further categorizes the relevance of specific metabolic pathways to individual intrinsic molecular subtypes of breast cancer. Based on mRNA expression data, the less aggressive luminal subtypes appear to rely on a balance between de novo fatty acid synthesis and oxidation as sources for both biomass and energy requirements, while basal-like, receptor negative subtypes overexpress genes involved in the utilization of exogenous fatty acids. With these differences in mind, treatments may need to be tailored to individual subtypes.
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spelling pubmed-54387462017-05-24 Fatty acid metabolism in breast cancer subtypes Monaco, Marie E. Oncotarget Review Dysregulation of fatty acid metabolism is recognized as a component of malignant transformation in many different cancers, including breast; yet the potential for targeting this pathway for prevention and/or treatment of cancer remains unrealized. Evidence indicates that proteins involved in both synthesis and oxidation of fatty acids play a pivotal role in the proliferation, migration and invasion of breast cancer cells. The following essay summarizes data implicating specific fatty acid metabolic enzymes in the genesis and progression of breast cancer, and further categorizes the relevance of specific metabolic pathways to individual intrinsic molecular subtypes of breast cancer. Based on mRNA expression data, the less aggressive luminal subtypes appear to rely on a balance between de novo fatty acid synthesis and oxidation as sources for both biomass and energy requirements, while basal-like, receptor negative subtypes overexpress genes involved in the utilization of exogenous fatty acids. With these differences in mind, treatments may need to be tailored to individual subtypes. Impact Journals LLC 2017-02-18 /pmc/articles/PMC5438746/ /pubmed/28412757 http://dx.doi.org/10.18632/oncotarget.15494 Text en Copyright: © 2017 Monaco http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Monaco, Marie E.
Fatty acid metabolism in breast cancer subtypes
title Fatty acid metabolism in breast cancer subtypes
title_full Fatty acid metabolism in breast cancer subtypes
title_fullStr Fatty acid metabolism in breast cancer subtypes
title_full_unstemmed Fatty acid metabolism in breast cancer subtypes
title_short Fatty acid metabolism in breast cancer subtypes
title_sort fatty acid metabolism in breast cancer subtypes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438746/
https://www.ncbi.nlm.nih.gov/pubmed/28412757
http://dx.doi.org/10.18632/oncotarget.15494
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