A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus

BACKGROUND: Sevoflurane is rarely used for the treatment of status asthmaticus. We report a case of sevoflurane hepatotoxicity in pregnancy with presentation similar to HELLP syndrome. CASE: A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7. She was nonresponsive...

Descripción completa

Detalles Bibliográficos
Autores principales: Parrott, Jessica, Tener, Mitch, Dennis, Katie, Sharpe, Matthew, Clark-Ganheart, Cecily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438830/
https://www.ncbi.nlm.nih.gov/pubmed/28555168
http://dx.doi.org/10.1155/2017/3547242
_version_ 1783237838677999616
author Parrott, Jessica
Tener, Mitch
Dennis, Katie
Sharpe, Matthew
Clark-Ganheart, Cecily
author_facet Parrott, Jessica
Tener, Mitch
Dennis, Katie
Sharpe, Matthew
Clark-Ganheart, Cecily
author_sort Parrott, Jessica
collection PubMed
description BACKGROUND: Sevoflurane is rarely used for the treatment of status asthmaticus. We report a case of sevoflurane hepatotoxicity in pregnancy with presentation similar to HELLP syndrome. CASE: A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7. She was nonresponsive to traditional therapy. Sevoflurane was added for a 24 hr period. Respiratory status improved. Extubation occurred on day 12. Workup for preeclampsia spectrum disorders occurred due to maternal hypertension. Given the atypical presentation and hepatotoxicity, a liver biopsy was performed. Histologic features suggested drug induced hepatic injury. Liver function subsequently normalized. She delivered a term neonate without short-term complications. CONCLUSION: The use of sevoflurane is a treatment option of status asthmaticus during pregnancy. Providers should be aware of the potential for hepatotoxicity.
format Online
Article
Text
id pubmed-5438830
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-54388302017-05-29 A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus Parrott, Jessica Tener, Mitch Dennis, Katie Sharpe, Matthew Clark-Ganheart, Cecily Case Rep Obstet Gynecol Case Report BACKGROUND: Sevoflurane is rarely used for the treatment of status asthmaticus. We report a case of sevoflurane hepatotoxicity in pregnancy with presentation similar to HELLP syndrome. CASE: A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7. She was nonresponsive to traditional therapy. Sevoflurane was added for a 24 hr period. Respiratory status improved. Extubation occurred on day 12. Workup for preeclampsia spectrum disorders occurred due to maternal hypertension. Given the atypical presentation and hepatotoxicity, a liver biopsy was performed. Histologic features suggested drug induced hepatic injury. Liver function subsequently normalized. She delivered a term neonate without short-term complications. CONCLUSION: The use of sevoflurane is a treatment option of status asthmaticus during pregnancy. Providers should be aware of the potential for hepatotoxicity. Hindawi 2017 2017-05-07 /pmc/articles/PMC5438830/ /pubmed/28555168 http://dx.doi.org/10.1155/2017/3547242 Text en Copyright © 2017 Jessica Parrott et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Parrott, Jessica
Tener, Mitch
Dennis, Katie
Sharpe, Matthew
Clark-Ganheart, Cecily
A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus
title A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus
title_full A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus
title_fullStr A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus
title_full_unstemmed A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus
title_short A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus
title_sort case of sevoflurane use during pregnancy in the management of persistent status asthmaticus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438830/
https://www.ncbi.nlm.nih.gov/pubmed/28555168
http://dx.doi.org/10.1155/2017/3547242
work_keys_str_mv AT parrottjessica acaseofsevofluraneuseduringpregnancyinthemanagementofpersistentstatusasthmaticus
AT tenermitch acaseofsevofluraneuseduringpregnancyinthemanagementofpersistentstatusasthmaticus
AT denniskatie acaseofsevofluraneuseduringpregnancyinthemanagementofpersistentstatusasthmaticus
AT sharpematthew acaseofsevofluraneuseduringpregnancyinthemanagementofpersistentstatusasthmaticus
AT clarkganheartcecily acaseofsevofluraneuseduringpregnancyinthemanagementofpersistentstatusasthmaticus
AT parrottjessica caseofsevofluraneuseduringpregnancyinthemanagementofpersistentstatusasthmaticus
AT tenermitch caseofsevofluraneuseduringpregnancyinthemanagementofpersistentstatusasthmaticus
AT denniskatie caseofsevofluraneuseduringpregnancyinthemanagementofpersistentstatusasthmaticus
AT sharpematthew caseofsevofluraneuseduringpregnancyinthemanagementofpersistentstatusasthmaticus
AT clarkganheartcecily caseofsevofluraneuseduringpregnancyinthemanagementofpersistentstatusasthmaticus

Ejemplares similares