Cargando…
Red Yeast Rice Protects Circulating Bone Marrow-Derived Proangiogenic Cells against High-Glucose-Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase-1
The inflammation and oxidative stress of bone marrow-derived proangiogenic cells (PACs), also named endothelial progenitor cells, triggered by hyperglycemia contributes significantly to vascular dysfunction. There is supporting evidence that the consumption of red yeast rice (RYR; Monascus purpureus...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438855/ https://www.ncbi.nlm.nih.gov/pubmed/28555162 http://dx.doi.org/10.1155/2017/3831750 |
_version_ | 1783237844711505920 |
---|---|
author | Liu, Jung-Tung Chen, Huey-Yi Chen, Wen-Chi Man, Kee-Ming Chen, Yung-Hsiang |
author_facet | Liu, Jung-Tung Chen, Huey-Yi Chen, Wen-Chi Man, Kee-Ming Chen, Yung-Hsiang |
author_sort | Liu, Jung-Tung |
collection | PubMed |
description | The inflammation and oxidative stress of bone marrow-derived proangiogenic cells (PACs), also named endothelial progenitor cells, triggered by hyperglycemia contributes significantly to vascular dysfunction. There is supporting evidence that the consumption of red yeast rice (RYR; Monascus purpureus-fermented rice) reduces the vascular complications of diabetes; however, the underlying mechanism remains unclear. This study aimed to elucidate the effects of RYR extract in PACs, focusing particularly on the role of a potent antioxidative enzyme, heme oxygenase-1 (HO-1). We found that treatment with RYR extract induced nuclear factor erythroid-2-related factor nuclear translocation and HO-1 mRNA and protein levels in PACs. RYR extract inhibited high-glucose-induced (30 mM) PAC senescence and the development of reactive oxygen species (ROS) in a dose-dependent manner. The HO-1 inducer cobalt protoporphyrin IX also decreased high-glucose-induced cell senescence and oxidative stress, whereas the HO-1 enzyme inhibitor zinc protoporphyrin IX and HO-1 small interfering RNA significantly reversed RYR extract-caused inhibition of senescence and reduction of oxidative stress in high-glucose-treated PACs. These results suggest that RYR extract serves as alternative and complementary medicine in the treatment of these diseases, by inducing HO-1, thereby decreasing the vascular complications of diabetes. |
format | Online Article Text |
id | pubmed-5438855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54388552017-05-29 Red Yeast Rice Protects Circulating Bone Marrow-Derived Proangiogenic Cells against High-Glucose-Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase-1 Liu, Jung-Tung Chen, Huey-Yi Chen, Wen-Chi Man, Kee-Ming Chen, Yung-Hsiang Oxid Med Cell Longev Research Article The inflammation and oxidative stress of bone marrow-derived proangiogenic cells (PACs), also named endothelial progenitor cells, triggered by hyperglycemia contributes significantly to vascular dysfunction. There is supporting evidence that the consumption of red yeast rice (RYR; Monascus purpureus-fermented rice) reduces the vascular complications of diabetes; however, the underlying mechanism remains unclear. This study aimed to elucidate the effects of RYR extract in PACs, focusing particularly on the role of a potent antioxidative enzyme, heme oxygenase-1 (HO-1). We found that treatment with RYR extract induced nuclear factor erythroid-2-related factor nuclear translocation and HO-1 mRNA and protein levels in PACs. RYR extract inhibited high-glucose-induced (30 mM) PAC senescence and the development of reactive oxygen species (ROS) in a dose-dependent manner. The HO-1 inducer cobalt protoporphyrin IX also decreased high-glucose-induced cell senescence and oxidative stress, whereas the HO-1 enzyme inhibitor zinc protoporphyrin IX and HO-1 small interfering RNA significantly reversed RYR extract-caused inhibition of senescence and reduction of oxidative stress in high-glucose-treated PACs. These results suggest that RYR extract serves as alternative and complementary medicine in the treatment of these diseases, by inducing HO-1, thereby decreasing the vascular complications of diabetes. Hindawi 2017 2017-05-06 /pmc/articles/PMC5438855/ /pubmed/28555162 http://dx.doi.org/10.1155/2017/3831750 Text en Copyright © 2017 Jung-Tung Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Jung-Tung Chen, Huey-Yi Chen, Wen-Chi Man, Kee-Ming Chen, Yung-Hsiang Red Yeast Rice Protects Circulating Bone Marrow-Derived Proangiogenic Cells against High-Glucose-Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase-1 |
title | Red Yeast Rice Protects Circulating Bone Marrow-Derived Proangiogenic Cells against High-Glucose-Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase-1 |
title_full | Red Yeast Rice Protects Circulating Bone Marrow-Derived Proangiogenic Cells against High-Glucose-Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase-1 |
title_fullStr | Red Yeast Rice Protects Circulating Bone Marrow-Derived Proangiogenic Cells against High-Glucose-Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase-1 |
title_full_unstemmed | Red Yeast Rice Protects Circulating Bone Marrow-Derived Proangiogenic Cells against High-Glucose-Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase-1 |
title_short | Red Yeast Rice Protects Circulating Bone Marrow-Derived Proangiogenic Cells against High-Glucose-Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase-1 |
title_sort | red yeast rice protects circulating bone marrow-derived proangiogenic cells against high-glucose-induced senescence and oxidative stress: the role of heme oxygenase-1 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438855/ https://www.ncbi.nlm.nih.gov/pubmed/28555162 http://dx.doi.org/10.1155/2017/3831750 |
work_keys_str_mv | AT liujungtung redyeastriceprotectscirculatingbonemarrowderivedproangiogeniccellsagainsthighglucoseinducedsenescenceandoxidativestresstheroleofhemeoxygenase1 AT chenhueyyi redyeastriceprotectscirculatingbonemarrowderivedproangiogeniccellsagainsthighglucoseinducedsenescenceandoxidativestresstheroleofhemeoxygenase1 AT chenwenchi redyeastriceprotectscirculatingbonemarrowderivedproangiogeniccellsagainsthighglucoseinducedsenescenceandoxidativestresstheroleofhemeoxygenase1 AT mankeeming redyeastriceprotectscirculatingbonemarrowderivedproangiogeniccellsagainsthighglucoseinducedsenescenceandoxidativestresstheroleofhemeoxygenase1 AT chenyunghsiang redyeastriceprotectscirculatingbonemarrowderivedproangiogeniccellsagainsthighglucoseinducedsenescenceandoxidativestresstheroleofhemeoxygenase1 |