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The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia

INTRODUCTION: Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activatio...

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Autores principales: Bajnok, Anna, Ivanova, Maria, Rigó, János, Toldi, Gergely
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438859/
https://www.ncbi.nlm.nih.gov/pubmed/28555090
http://dx.doi.org/10.1155/2017/8045161
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author Bajnok, Anna
Ivanova, Maria
Rigó, János
Toldi, Gergely
author_facet Bajnok, Anna
Ivanova, Maria
Rigó, János
Toldi, Gergely
author_sort Bajnok, Anna
collection PubMed
description INTRODUCTION: Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, the results are controversial and a comprehensive analysis of activation markers is lacking. The characteristics of cellular adhesion molecules in preeclampsia are yet to be described. MATERIAL AND METHODS: Peripheral blood samples of 18 preeclamptic patients and 20 healthy pregnant women in the third trimester were evaluated using flow cytometry to characterize the cell surface expression of T lymphocyte activation markers and selectins. RESULTS: We found an elevated ratio of HLA-DR and CD122-, CD62E-, and CD62L-expressing cells among the CD4+ T lymphocytes in PE in comparison to healthy pregnancy. No alterations were found in the prevalence of CD69-, CD25-, and CD62P-expressing lymphocytes and CD11c-expressing monocytes. CONCLUSIONS: Our findings support the role of activated T lymphocytes and specific cell adhesion molecules in the pathogenesis of preeclampsia.
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spelling pubmed-54388592017-05-29 The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia Bajnok, Anna Ivanova, Maria Rigó, János Toldi, Gergely Mediators Inflamm Research Article INTRODUCTION: Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, the results are controversial and a comprehensive analysis of activation markers is lacking. The characteristics of cellular adhesion molecules in preeclampsia are yet to be described. MATERIAL AND METHODS: Peripheral blood samples of 18 preeclamptic patients and 20 healthy pregnant women in the third trimester were evaluated using flow cytometry to characterize the cell surface expression of T lymphocyte activation markers and selectins. RESULTS: We found an elevated ratio of HLA-DR and CD122-, CD62E-, and CD62L-expressing cells among the CD4+ T lymphocytes in PE in comparison to healthy pregnancy. No alterations were found in the prevalence of CD69-, CD25-, and CD62P-expressing lymphocytes and CD11c-expressing monocytes. CONCLUSIONS: Our findings support the role of activated T lymphocytes and specific cell adhesion molecules in the pathogenesis of preeclampsia. Hindawi 2017 2017-05-07 /pmc/articles/PMC5438859/ /pubmed/28555090 http://dx.doi.org/10.1155/2017/8045161 Text en Copyright © 2017 Anna Bajnok et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bajnok, Anna
Ivanova, Maria
Rigó, János
Toldi, Gergely
The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia
title The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia
title_full The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia
title_fullStr The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia
title_full_unstemmed The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia
title_short The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia
title_sort distribution of activation markers and selectins on peripheral t lymphocytes in preeclampsia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438859/
https://www.ncbi.nlm.nih.gov/pubmed/28555090
http://dx.doi.org/10.1155/2017/8045161
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