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In Vitro Anti-Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts

BACKGROUND: A new shampoo with anti-Malassezia properties obtained from various plants is required to provide seborrheic dermatitis patients with a wider range of treatment options. OBJECTIVE: The aim of this study was to obtain in vitro susceptibility profiles of Malassezia restricta and M. globosa...

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Detalles Bibliográficos
Autores principales: Han, Song Hee, Hur, Min Seok, Kim, Min Jung, Jung, Won Hee, Park, Minji, Kim, Jeong Hwan, Shin, Hong Ju, Choe, Yong Beom, Ahn, Kyu Joong, Lee, Yang Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438939/
https://www.ncbi.nlm.nih.gov/pubmed/28566909
http://dx.doi.org/10.5021/ad.2017.29.3.321
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author Han, Song Hee
Hur, Min Seok
Kim, Min Jung
Jung, Won Hee
Park, Minji
Kim, Jeong Hwan
Shin, Hong Ju
Choe, Yong Beom
Ahn, Kyu Joong
Lee, Yang Won
author_facet Han, Song Hee
Hur, Min Seok
Kim, Min Jung
Jung, Won Hee
Park, Minji
Kim, Jeong Hwan
Shin, Hong Ju
Choe, Yong Beom
Ahn, Kyu Joong
Lee, Yang Won
author_sort Han, Song Hee
collection PubMed
description BACKGROUND: A new shampoo with anti-Malassezia properties obtained from various plants is required to provide seborrheic dermatitis patients with a wider range of treatment options. OBJECTIVE: The aim of this study was to obtain in vitro susceptibility profiles of Malassezia restricta and M. globosa, the most important pathogenic organisms in the development of seborrheic dermatitis, to the plant extracts used in commercial anti-dandruff shampoos. METHODS: Minimal inhibitory concentrations (MICs) were determined for eight candidate plant extracts and two plant-derived natural products diluted with Leeming and Notman medium to final concentrations of 0.016 to 1 mg/ml. RESULTS: Castanea crenata shell, Camellia sinensis leaf, and oil-soluble Glycyrrhiza extracts presented relatively low MIC values (≤0.5 mg/ml) against both strains. The C. crenata shell and oil-soluble Glycyrrhiza extracts demonstrated especially high anti-Malassezia activity, suggesting their potential use in the treatment of seborrheic dermatitis. The extracts also showed fungistatic activity against other common facultative pathogenic yeasts, Cryptococcus and Candida. CONCLUSION: C. crenata shell and oil-soluble Glycyrrhiza extracts could potentially be used as active ingredients in anti-seborrheic and anti-dandruff shampoo formulations. They could be helpful for repeated treatments and regular prophylaxis of scalp seborrheic dermatitis.
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spelling pubmed-54389392017-06-01 In Vitro Anti-Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts Han, Song Hee Hur, Min Seok Kim, Min Jung Jung, Won Hee Park, Minji Kim, Jeong Hwan Shin, Hong Ju Choe, Yong Beom Ahn, Kyu Joong Lee, Yang Won Ann Dermatol Original Article BACKGROUND: A new shampoo with anti-Malassezia properties obtained from various plants is required to provide seborrheic dermatitis patients with a wider range of treatment options. OBJECTIVE: The aim of this study was to obtain in vitro susceptibility profiles of Malassezia restricta and M. globosa, the most important pathogenic organisms in the development of seborrheic dermatitis, to the plant extracts used in commercial anti-dandruff shampoos. METHODS: Minimal inhibitory concentrations (MICs) were determined for eight candidate plant extracts and two plant-derived natural products diluted with Leeming and Notman medium to final concentrations of 0.016 to 1 mg/ml. RESULTS: Castanea crenata shell, Camellia sinensis leaf, and oil-soluble Glycyrrhiza extracts presented relatively low MIC values (≤0.5 mg/ml) against both strains. The C. crenata shell and oil-soluble Glycyrrhiza extracts demonstrated especially high anti-Malassezia activity, suggesting their potential use in the treatment of seborrheic dermatitis. The extracts also showed fungistatic activity against other common facultative pathogenic yeasts, Cryptococcus and Candida. CONCLUSION: C. crenata shell and oil-soluble Glycyrrhiza extracts could potentially be used as active ingredients in anti-seborrheic and anti-dandruff shampoo formulations. They could be helpful for repeated treatments and regular prophylaxis of scalp seborrheic dermatitis. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2017-06 2017-05-11 /pmc/articles/PMC5438939/ /pubmed/28566909 http://dx.doi.org/10.5021/ad.2017.29.3.321 Text en Copyright © 2017 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Han, Song Hee
Hur, Min Seok
Kim, Min Jung
Jung, Won Hee
Park, Minji
Kim, Jeong Hwan
Shin, Hong Ju
Choe, Yong Beom
Ahn, Kyu Joong
Lee, Yang Won
In Vitro Anti-Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts
title In Vitro Anti-Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts
title_full In Vitro Anti-Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts
title_fullStr In Vitro Anti-Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts
title_full_unstemmed In Vitro Anti-Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts
title_short In Vitro Anti-Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts
title_sort in vitro anti-malassezia activity of castanea crenata shell and oil-soluble glycyrrhiza extracts
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438939/
https://www.ncbi.nlm.nih.gov/pubmed/28566909
http://dx.doi.org/10.5021/ad.2017.29.3.321
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