Puzzling Out Synaptic Vesicle 2 Family Members Functions

Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 protein...

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Autores principales: Bartholome, Odile, Van den Ackerveken, Priscilla, Sánchez Gil, Judit, de la Brassinne Bonardeaux, Orianne, Leprince, Pierre, Franzen, Rachelle, Rogister, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438990/
https://www.ncbi.nlm.nih.gov/pubmed/28588450
http://dx.doi.org/10.3389/fnmol.2017.00148
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author Bartholome, Odile
Van den Ackerveken, Priscilla
Sánchez Gil, Judit
de la Brassinne Bonardeaux, Orianne
Leprince, Pierre
Franzen, Rachelle
Rogister, Bernard
author_facet Bartholome, Odile
Van den Ackerveken, Priscilla
Sánchez Gil, Judit
de la Brassinne Bonardeaux, Orianne
Leprince, Pierre
Franzen, Rachelle
Rogister, Bernard
author_sort Bartholome, Odile
collection PubMed
description Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, Schizophrenia (SCZ), Alzheimer’s or Parkinson’s disease. In this review article, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders.
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spelling pubmed-54389902017-06-06 Puzzling Out Synaptic Vesicle 2 Family Members Functions Bartholome, Odile Van den Ackerveken, Priscilla Sánchez Gil, Judit de la Brassinne Bonardeaux, Orianne Leprince, Pierre Franzen, Rachelle Rogister, Bernard Front Mol Neurosci Neuroscience Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, Schizophrenia (SCZ), Alzheimer’s or Parkinson’s disease. In this review article, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders. Frontiers Media S.A. 2017-05-22 /pmc/articles/PMC5438990/ /pubmed/28588450 http://dx.doi.org/10.3389/fnmol.2017.00148 Text en Copyright © 2017 Bartholome, Van den Ackerveken, Sánchez Gil, de la Brassinne Bonardeaux, Leprince, Franzen and Rogister. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bartholome, Odile
Van den Ackerveken, Priscilla
Sánchez Gil, Judit
de la Brassinne Bonardeaux, Orianne
Leprince, Pierre
Franzen, Rachelle
Rogister, Bernard
Puzzling Out Synaptic Vesicle 2 Family Members Functions
title Puzzling Out Synaptic Vesicle 2 Family Members Functions
title_full Puzzling Out Synaptic Vesicle 2 Family Members Functions
title_fullStr Puzzling Out Synaptic Vesicle 2 Family Members Functions
title_full_unstemmed Puzzling Out Synaptic Vesicle 2 Family Members Functions
title_short Puzzling Out Synaptic Vesicle 2 Family Members Functions
title_sort puzzling out synaptic vesicle 2 family members functions
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438990/
https://www.ncbi.nlm.nih.gov/pubmed/28588450
http://dx.doi.org/10.3389/fnmol.2017.00148
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