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Egr2 and 3 Inhibit T-bet–Mediated IFN-γ Production in T Cells

T-bet is important for differentiation of cytotoxic CD8 and Th1 CD4 T cells. We have discovered that Egr2 and 3 are potent inhibitors of T-bet function in CD4 and CD8 effector T cells. Egr2 and 3 were essential to suppress Th1 differentiation in Th2 and Th17 conditions in vitro and also to control I...

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Detalles Bibliográficos
Autores principales:	Singh, Randeep, Miao, Tizong, Symonds, Alistair L. J., Omodho, Becky, Li, Suling, Wang, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2017
Materias:	Infectious Disease and Host Response
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439026/ https://www.ncbi.nlm.nih.gov/pubmed/28455436 http://dx.doi.org/10.4049/jimmunol.1602010

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