Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome

Neurogenesis impairment is considered a major determinant of the intellectual disability that characterizes Down syndrome (DS), a genetic condition caused by triplication of chromosome 21. Previous evidence obtained in the Ts65Dn mouse model of DS showed that the triplicated gene APP (amyloid precur...

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Detalles Bibliográficos
Autores principales: Stagni, Fiorenza, Raspanti, Alessandra, Giacomini, Andrea, Guidi, Sandra, Emili, Marco, Ciani, Elisabetta, Giuliani, Alessandro, Bighinati, Andrea, Calzà, Laura, Magistretti, Jacopo, Bartesaghi, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439029/
https://www.ncbi.nlm.nih.gov/pubmed/28359846
http://dx.doi.org/10.1016/j.nbd.2017.03.012

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