Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein

Advances in HIV-1 envelope glycoprotein (Env) design generate native-like trimers and high-resolution clade A, B, and G structures and elicit neutralizing antibodies. However, a high-resolution clade C structure is critical, as this subtype accounts for the majority of HIV infections worldwide, but...

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Detalles Bibliográficos
Autores principales: Guenaga, Javier, Garces, Fernando, de Val, Natalia, Stanfield, Robyn L., Dubrovskaya, Viktoriya, Higgins, Brett, Carrette, Barbara, Ward, Andrew B., Wilson, Ian A., Wyatt, Richard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439057/
https://www.ncbi.nlm.nih.gov/pubmed/28514686
http://dx.doi.org/10.1016/j.immuni.2017.04.014

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