The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice

San Leng powder extract has been used as medicinal compound for the prevention and treatment of cancers. The antitumor activity of SLPE was determined by treating BALB/C mice harboring a human gastric cancer xenograft with SPLE for 17 days. Mice were also treated with fluorouracil (5-Fu, 25 mg/kg) o...

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Detalles Bibliográficos
Autores principales: Yu, Chen, Ji, Ai-Jun, Lu, Jian-Wei, Liu, Shi-Jia, Sun, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439070/
https://www.ncbi.nlm.nih.gov/pubmed/28567097
http://dx.doi.org/10.1155/2017/1052125
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author Yu, Chen
Ji, Ai-Jun
Lu, Jian-Wei
Liu, Shi-Jia
Sun, Yu
author_facet Yu, Chen
Ji, Ai-Jun
Lu, Jian-Wei
Liu, Shi-Jia
Sun, Yu
author_sort Yu, Chen
collection PubMed
description San Leng powder extract has been used as medicinal compound for the prevention and treatment of cancers. The antitumor activity of SLPE was determined by treating BALB/C mice harboring a human gastric cancer xenograft with SPLE for 17 days. Mice were also treated with fluorouracil (5-Fu, 25 mg/kg) or a combination of SLPE and 5-Fu. Our results indicate that the inhibition of tumor growth by SLPE might be due to a block in the cell cycle and the induction of apoptosis. These results suggest that SLPE might be useful in the treatment of gastric cancer.
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spelling pubmed-54390702017-05-31 The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice Yu, Chen Ji, Ai-Jun Lu, Jian-Wei Liu, Shi-Jia Sun, Yu Evid Based Complement Alternat Med Research Article San Leng powder extract has been used as medicinal compound for the prevention and treatment of cancers. The antitumor activity of SLPE was determined by treating BALB/C mice harboring a human gastric cancer xenograft with SPLE for 17 days. Mice were also treated with fluorouracil (5-Fu, 25 mg/kg) or a combination of SLPE and 5-Fu. Our results indicate that the inhibition of tumor growth by SLPE might be due to a block in the cell cycle and the induction of apoptosis. These results suggest that SLPE might be useful in the treatment of gastric cancer. Hindawi 2017 2017-05-08 /pmc/articles/PMC5439070/ /pubmed/28567097 http://dx.doi.org/10.1155/2017/1052125 Text en Copyright © 2017 Chen Yu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yu, Chen
Ji, Ai-Jun
Lu, Jian-Wei
Liu, Shi-Jia
Sun, Yu
The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice
title The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice
title_full The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice
title_fullStr The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice
title_full_unstemmed The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice
title_short The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice
title_sort antigastric cancer activity of san leng powder extract induces apoptosis in balb/c bearing-sgc-7901 mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439070/
https://www.ncbi.nlm.nih.gov/pubmed/28567097
http://dx.doi.org/10.1155/2017/1052125
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