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PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides
Background. Bullous pemphigoid is an autoimmune subepidermal blistering skin disease in which autoantibodies are directed against components of the basement membrane. The disease primarily affects the elderly people and in most of the patients inducing factors cannot be identified. Herein, we report...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439255/ https://www.ncbi.nlm.nih.gov/pubmed/28567313 http://dx.doi.org/10.1155/2017/6134752 |
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author | Özkesici, Birgül Koç, Saliha Akman-Karakaş, Ayşe Yılmaz, Ertan Başsorgun, İbrahim Cumhur Uzun, Soner |
author_facet | Özkesici, Birgül Koç, Saliha Akman-Karakaş, Ayşe Yılmaz, Ertan Başsorgun, İbrahim Cumhur Uzun, Soner |
author_sort | Özkesici, Birgül |
collection | PubMed |
description | Background. Bullous pemphigoid is an autoimmune subepidermal blistering skin disease in which autoantibodies are directed against components of the basement membrane. The disease primarily affects the elderly people and in most of the patients inducing factors cannot be identified. Herein, we report a case of BP that occurred in a patient who was receiving PUVA therapy for the treatment of mycosis fungoides. Main Observation. A 26-year-old woman with mycosis fungoides developed blisters while receiving PUVA therapy. On physical examination tense bullae on the normal skin, remnants of blisters, and erosions were observed on her breasts, the chest wall, and the upper abdomen. Histopathological investigations revealed subepidermal blisters with eosinophilic infiltration and in direct immunofluorescence examination linear deposition of IgG along the basement membrane zone was observed. The diagnosis of bullous pemphigoid was also confirmed by ELISA and BIOCHIP mosaic-based indirect immunofluorescence test. Conclusions. PUVA therapy is an extremely rare physical factor capable of inducing bullous pemphigoid. So the development of blistering lesions during PUVA therapy may be suggestive sign of a bullous disease such as bullous pemphigoid and it should be excluded with proper clinical and laboratory approaches immediately after withdrawal of PUVA therapy. |
format | Online Article Text |
id | pubmed-5439255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54392552017-05-31 PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides Özkesici, Birgül Koç, Saliha Akman-Karakaş, Ayşe Yılmaz, Ertan Başsorgun, İbrahim Cumhur Uzun, Soner Case Rep Dermatol Med Case Report Background. Bullous pemphigoid is an autoimmune subepidermal blistering skin disease in which autoantibodies are directed against components of the basement membrane. The disease primarily affects the elderly people and in most of the patients inducing factors cannot be identified. Herein, we report a case of BP that occurred in a patient who was receiving PUVA therapy for the treatment of mycosis fungoides. Main Observation. A 26-year-old woman with mycosis fungoides developed blisters while receiving PUVA therapy. On physical examination tense bullae on the normal skin, remnants of blisters, and erosions were observed on her breasts, the chest wall, and the upper abdomen. Histopathological investigations revealed subepidermal blisters with eosinophilic infiltration and in direct immunofluorescence examination linear deposition of IgG along the basement membrane zone was observed. The diagnosis of bullous pemphigoid was also confirmed by ELISA and BIOCHIP mosaic-based indirect immunofluorescence test. Conclusions. PUVA therapy is an extremely rare physical factor capable of inducing bullous pemphigoid. So the development of blistering lesions during PUVA therapy may be suggestive sign of a bullous disease such as bullous pemphigoid and it should be excluded with proper clinical and laboratory approaches immediately after withdrawal of PUVA therapy. Hindawi 2017 2017-04-16 /pmc/articles/PMC5439255/ /pubmed/28567313 http://dx.doi.org/10.1155/2017/6134752 Text en Copyright © 2017 Birgül Özkesici et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Özkesici, Birgül Koç, Saliha Akman-Karakaş, Ayşe Yılmaz, Ertan Başsorgun, İbrahim Cumhur Uzun, Soner PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides |
title | PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides |
title_full | PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides |
title_fullStr | PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides |
title_full_unstemmed | PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides |
title_short | PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides |
title_sort | puva induced bullous pemphigoid in a patient with mycosis fungoides |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439255/ https://www.ncbi.nlm.nih.gov/pubmed/28567313 http://dx.doi.org/10.1155/2017/6134752 |
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