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Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration

Chitosan is a naturally occurring polysaccharide obtained from chitin, present in abundance in the exoskeletons of crustaceans and insects. It has aroused great interest as a biomaterial for tissue engineering on account of its biocompatibility and biodegradation and its affinity for biomolecules. A...

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Autores principales: Ribeiro, José Carlos Viana, Vieira, Rodrigo Silveira, Melo, Iracema Matos, Araújo, Vilana Maria Adriano, Lima, Vilma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439263/
https://www.ncbi.nlm.nih.gov/pubmed/28567441
http://dx.doi.org/10.1155/2017/8639898
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author Ribeiro, José Carlos Viana
Vieira, Rodrigo Silveira
Melo, Iracema Matos
Araújo, Vilana Maria Adriano
Lima, Vilma
author_facet Ribeiro, José Carlos Viana
Vieira, Rodrigo Silveira
Melo, Iracema Matos
Araújo, Vilana Maria Adriano
Lima, Vilma
author_sort Ribeiro, José Carlos Viana
collection PubMed
description Chitosan is a naturally occurring polysaccharide obtained from chitin, present in abundance in the exoskeletons of crustaceans and insects. It has aroused great interest as a biomaterial for tissue engineering on account of its biocompatibility and biodegradation and its affinity for biomolecules. A significant number of research groups have investigated the application of chitosan as scaffolds for tissue regeneration. However, there is a wide variability in terms of physicochemical characteristics of chitosan used in some studies and its combinations with other biomaterials, making it difficult to compare results and standardize its properties. The current systematic review of literature on the use of chitosan for tissue regeneration consisted of a study of 478 articles in the PubMed database, which resulted, after applying inclusion criteria, in the selection of 61 catalogued, critically analysed works. The results demonstrated the effectiveness of chitosan-based biomaterials in 93.4% of the studies reviewed, whether or not combined with cells and growth factors, in the regeneration of various types of tissues in animals. However, the absence of clinical studies in humans, the inadequate experimental designs, and the lack of information concerning chitosan's characteristics limit the reproducibility and relevance of studies and the clinical applicability of chitosan.
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spelling pubmed-54392632017-05-31 Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration Ribeiro, José Carlos Viana Vieira, Rodrigo Silveira Melo, Iracema Matos Araújo, Vilana Maria Adriano Lima, Vilma ScientificWorldJournal Review Article Chitosan is a naturally occurring polysaccharide obtained from chitin, present in abundance in the exoskeletons of crustaceans and insects. It has aroused great interest as a biomaterial for tissue engineering on account of its biocompatibility and biodegradation and its affinity for biomolecules. A significant number of research groups have investigated the application of chitosan as scaffolds for tissue regeneration. However, there is a wide variability in terms of physicochemical characteristics of chitosan used in some studies and its combinations with other biomaterials, making it difficult to compare results and standardize its properties. The current systematic review of literature on the use of chitosan for tissue regeneration consisted of a study of 478 articles in the PubMed database, which resulted, after applying inclusion criteria, in the selection of 61 catalogued, critically analysed works. The results demonstrated the effectiveness of chitosan-based biomaterials in 93.4% of the studies reviewed, whether or not combined with cells and growth factors, in the regeneration of various types of tissues in animals. However, the absence of clinical studies in humans, the inadequate experimental designs, and the lack of information concerning chitosan's characteristics limit the reproducibility and relevance of studies and the clinical applicability of chitosan. Hindawi 2017 2017-04-16 /pmc/articles/PMC5439263/ /pubmed/28567441 http://dx.doi.org/10.1155/2017/8639898 Text en Copyright © 2017 José Carlos Viana Ribeiro et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ribeiro, José Carlos Viana
Vieira, Rodrigo Silveira
Melo, Iracema Matos
Araújo, Vilana Maria Adriano
Lima, Vilma
Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration
title Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration
title_full Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration
title_fullStr Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration
title_full_unstemmed Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration
title_short Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration
title_sort versatility of chitosan-based biomaterials and their use as scaffolds for tissue regeneration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439263/
https://www.ncbi.nlm.nih.gov/pubmed/28567441
http://dx.doi.org/10.1155/2017/8639898
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