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Alpha-particle fluence in radiobiological experiments

Two methods were proposed for determining alpha-particle fluence for radiobiological experiments. The first involved calculating the probabilities of hitting the target for alpha particles emitted from a source through Monte Carlo simulations, which when multiplied by the activity of the source gave...

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Autores principales: Nikezic, Dragoslav, Yu, Kwan Ngok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439373/
https://www.ncbi.nlm.nih.gov/pubmed/27811200
http://dx.doi.org/10.1093/jrr/rrw106
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author Nikezic, Dragoslav
Yu, Kwan Ngok
author_facet Nikezic, Dragoslav
Yu, Kwan Ngok
author_sort Nikezic, Dragoslav
collection PubMed
description Two methods were proposed for determining alpha-particle fluence for radiobiological experiments. The first involved calculating the probabilities of hitting the target for alpha particles emitted from a source through Monte Carlo simulations, which when multiplied by the activity of the source gave the fluence at the target. The second relied on the number of chemically etched alpha-particle tracks developed on a solid-state nuclear track detector (SSNTD) that was irradiated by an alpha-particle source. The etching efficiencies (defined as percentages of latent tracks created by alpha particles from the source that could develop to become visible tracks upon chemical etching) were computed through Monte Carlo simulations, which when multiplied by the experimentally counted number of visible tracks would also give the fluence at the target. We studied alpha particles with an energy of 5.486 MeV emitted from an (241)Am source, and considered the alpha-particle tracks developed on polyallyldiglycol carbonate film, which is a common SSNTD. Our results showed that the etching efficiencies were equal to one for source–film distances of from 0.6 to 3.5 cm for a circular film of radius of 1 cm, and for source–film distances of from 1 to 3 cm for circular film of radius of 2 cm. For circular film with a radius of 3 cm, the etching efficiencies never reached 1. On the other hand, the hit probability decreased monotonically with increase in the source–target distance, and fell to zero when the source–target distance was larger than the particle range in air.
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spelling pubmed-54393732017-05-25 Alpha-particle fluence in radiobiological experiments Nikezic, Dragoslav Yu, Kwan Ngok J Radiat Res Biology Two methods were proposed for determining alpha-particle fluence for radiobiological experiments. The first involved calculating the probabilities of hitting the target for alpha particles emitted from a source through Monte Carlo simulations, which when multiplied by the activity of the source gave the fluence at the target. The second relied on the number of chemically etched alpha-particle tracks developed on a solid-state nuclear track detector (SSNTD) that was irradiated by an alpha-particle source. The etching efficiencies (defined as percentages of latent tracks created by alpha particles from the source that could develop to become visible tracks upon chemical etching) were computed through Monte Carlo simulations, which when multiplied by the experimentally counted number of visible tracks would also give the fluence at the target. We studied alpha particles with an energy of 5.486 MeV emitted from an (241)Am source, and considered the alpha-particle tracks developed on polyallyldiglycol carbonate film, which is a common SSNTD. Our results showed that the etching efficiencies were equal to one for source–film distances of from 0.6 to 3.5 cm for a circular film of radius of 1 cm, and for source–film distances of from 1 to 3 cm for circular film of radius of 2 cm. For circular film with a radius of 3 cm, the etching efficiencies never reached 1. On the other hand, the hit probability decreased monotonically with increase in the source–target distance, and fell to zero when the source–target distance was larger than the particle range in air. Oxford University Press 2017-03 2016-11-03 /pmc/articles/PMC5439373/ /pubmed/27811200 http://dx.doi.org/10.1093/jrr/rrw106 Text en © The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the originalwork is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Biology
Nikezic, Dragoslav
Yu, Kwan Ngok
Alpha-particle fluence in radiobiological experiments
title Alpha-particle fluence in radiobiological experiments
title_full Alpha-particle fluence in radiobiological experiments
title_fullStr Alpha-particle fluence in radiobiological experiments
title_full_unstemmed Alpha-particle fluence in radiobiological experiments
title_short Alpha-particle fluence in radiobiological experiments
title_sort alpha-particle fluence in radiobiological experiments
topic Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439373/
https://www.ncbi.nlm.nih.gov/pubmed/27811200
http://dx.doi.org/10.1093/jrr/rrw106
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