Axonal microRNAs: localization, function and regulatory mechanism during axon development

Subcellular localization and translation of messenger RNAs are essential for the regulation of neuronal development and synaptic function. As post-transcriptional regulators, microRNAs (miRNAs) have been emerging as central players in the development and maturation of the nervous system. Recent disc...

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Detalles Bibliográficos
Autores principales: Wang, Bin, Bao, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439374/
https://www.ncbi.nlm.nih.gov/pubmed/27932485
http://dx.doi.org/10.1093/jmcb/mjw050
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author Wang, Bin
Bao, Lan
author_facet Wang, Bin
Bao, Lan
author_sort Wang, Bin
collection PubMed
description Subcellular localization and translation of messenger RNAs are essential for the regulation of neuronal development and synaptic function. As post-transcriptional regulators, microRNAs (miRNAs) have been emerging as central players in the development and maturation of the nervous system. Recent discoveries reveal the critical functions of miRNAs in the axon of neurons via multiple pathways of molecular regulation. Here, we introduce methods for isolating axonal miRNAs and review recent findings on the localization and function as well as regulatory mechanism of axonal miRNAs during axon development.
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spelling pubmed-54393742017-05-25 Axonal microRNAs: localization, function and regulatory mechanism during axon development Wang, Bin Bao, Lan J Mol Cell Biol Invited Review Subcellular localization and translation of messenger RNAs are essential for the regulation of neuronal development and synaptic function. As post-transcriptional regulators, microRNAs (miRNAs) have been emerging as central players in the development and maturation of the nervous system. Recent discoveries reveal the critical functions of miRNAs in the axon of neurons via multiple pathways of molecular regulation. Here, we introduce methods for isolating axonal miRNAs and review recent findings on the localization and function as well as regulatory mechanism of axonal miRNAs during axon development. Oxford University Press 2017-04 2017-01-06 /pmc/articles/PMC5439374/ /pubmed/27932485 http://dx.doi.org/10.1093/jmcb/mjw050 Text en © The Author (2017). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Invited Review
Wang, Bin
Bao, Lan
Axonal microRNAs: localization, function and regulatory mechanism during axon development
title Axonal microRNAs: localization, function and regulatory mechanism during axon development
title_full Axonal microRNAs: localization, function and regulatory mechanism during axon development
title_fullStr Axonal microRNAs: localization, function and regulatory mechanism during axon development
title_full_unstemmed Axonal microRNAs: localization, function and regulatory mechanism during axon development
title_short Axonal microRNAs: localization, function and regulatory mechanism during axon development
title_sort axonal micrornas: localization, function and regulatory mechanism during axon development
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439374/
https://www.ncbi.nlm.nih.gov/pubmed/27932485
http://dx.doi.org/10.1093/jmcb/mjw050
work_keys_str_mv AT wangbin axonalmicrornaslocalizationfunctionandregulatorymechanismduringaxondevelopment
AT baolan axonalmicrornaslocalizationfunctionandregulatorymechanismduringaxondevelopment

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