Role of Mdm2 and Mdmx in DNA repair

Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on genome instability was shown to be at least, in part, independent of p53. Both Mdm2 and Mdmx inhibit DNA break repair through their associati...

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Detalles Bibliográficos
Autor principal: Eischen, Christine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439402/
https://www.ncbi.nlm.nih.gov/pubmed/27932484
http://dx.doi.org/10.1093/jmcb/mjw052
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author Eischen, Christine M.
author_facet Eischen, Christine M.
author_sort Eischen, Christine M.
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description Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on genome instability was shown to be at least, in part, independent of p53. Both Mdm2 and Mdmx inhibit DNA break repair through their association with the Mre11/Rad50/Nbs1 DNA repair complex. Recent evidence indicates that harnessing Mdm2 and/or Mdmx-mediated inhibition of DNA break repair in cancer cells could provide a therapeutic opportunity, particularly for those malignancies that have lost functional p53.
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spelling pubmed-54394022017-05-25 Role of Mdm2 and Mdmx in DNA repair Eischen, Christine M. J Mol Cell Biol Invited Review Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on genome instability was shown to be at least, in part, independent of p53. Both Mdm2 and Mdmx inhibit DNA break repair through their association with the Mre11/Rad50/Nbs1 DNA repair complex. Recent evidence indicates that harnessing Mdm2 and/or Mdmx-mediated inhibition of DNA break repair in cancer cells could provide a therapeutic opportunity, particularly for those malignancies that have lost functional p53. Oxford University Press 2017-02 2017-01-06 /pmc/articles/PMC5439402/ /pubmed/27932484 http://dx.doi.org/10.1093/jmcb/mjw052 Text en © The Author (2017). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Invited Review
Eischen, Christine M.
Role of Mdm2 and Mdmx in DNA repair
title Role of Mdm2 and Mdmx in DNA repair
title_full Role of Mdm2 and Mdmx in DNA repair
title_fullStr Role of Mdm2 and Mdmx in DNA repair
title_full_unstemmed Role of Mdm2 and Mdmx in DNA repair
title_short Role of Mdm2 and Mdmx in DNA repair
title_sort role of mdm2 and mdmx in dna repair
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439402/
https://www.ncbi.nlm.nih.gov/pubmed/27932484
http://dx.doi.org/10.1093/jmcb/mjw052
work_keys_str_mv AT eischenchristinem roleofmdm2andmdmxindnarepair

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