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Role of Mdm2 and Mdmx in DNA repair
Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on genome instability was shown to be at least, in part, independent of p53. Both Mdm2 and Mdmx inhibit DNA break repair through their associati...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439402/ https://www.ncbi.nlm.nih.gov/pubmed/27932484 http://dx.doi.org/10.1093/jmcb/mjw052 |