The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes

In this study, we evaluated whether the protective potential of resveratrol (RSV; 3,5,4′-trihydroxy-trans-stilbene) against γ-radiation caused damages in peripheral blood lymphocyte of mice. Resveratrol as a polyphenolic compound scavenges free radicals. Various doses of RSV were administered intrap...

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Autores principales: Koohian, Farideh, Shanei, Ahmad, Shahbazi-Gahrouei, Daryoush, Hejazi, Seyed Hossein, Moradi, Mohammad-Taghi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439647/
https://www.ncbi.nlm.nih.gov/pubmed/28566983
http://dx.doi.org/10.1177/1559325817705699
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author Koohian, Farideh
Shanei, Ahmad
Shahbazi-Gahrouei, Daryoush
Hejazi, Seyed Hossein
Moradi, Mohammad-Taghi
author_facet Koohian, Farideh
Shanei, Ahmad
Shahbazi-Gahrouei, Daryoush
Hejazi, Seyed Hossein
Moradi, Mohammad-Taghi
author_sort Koohian, Farideh
collection PubMed
description In this study, we evaluated whether the protective potential of resveratrol (RSV; 3,5,4′-trihydroxy-trans-stilbene) against γ-radiation caused damages in peripheral blood lymphocyte of mice. Resveratrol as a polyphenolic compound scavenges free radicals. Various doses of RSV were administered intraperitoneally 2 hours to adult male mice before a single dose of whole-body γ-irradiation (2 Gy). To assess the protective ability of RSV, the alkaline comet assay in blood lymphocyte of mice was performed and the total comet score was evaluated. The results of the alkaline comet assay showed that RSV significantly inhibited radiation-induced DNA damage. We observed that RSV protects blood lymphocyte against radiation-induced damage in mice.
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spelling pubmed-54396472017-05-31 The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes Koohian, Farideh Shanei, Ahmad Shahbazi-Gahrouei, Daryoush Hejazi, Seyed Hossein Moradi, Mohammad-Taghi Dose Response Original Article In this study, we evaluated whether the protective potential of resveratrol (RSV; 3,5,4′-trihydroxy-trans-stilbene) against γ-radiation caused damages in peripheral blood lymphocyte of mice. Resveratrol as a polyphenolic compound scavenges free radicals. Various doses of RSV were administered intraperitoneally 2 hours to adult male mice before a single dose of whole-body γ-irradiation (2 Gy). To assess the protective ability of RSV, the alkaline comet assay in blood lymphocyte of mice was performed and the total comet score was evaluated. The results of the alkaline comet assay showed that RSV significantly inhibited radiation-induced DNA damage. We observed that RSV protects blood lymphocyte against radiation-induced damage in mice. SAGE Publications 2017-05-18 /pmc/articles/PMC5439647/ /pubmed/28566983 http://dx.doi.org/10.1177/1559325817705699 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Koohian, Farideh
Shanei, Ahmad
Shahbazi-Gahrouei, Daryoush
Hejazi, Seyed Hossein
Moradi, Mohammad-Taghi
The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes
title The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes
title_full The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes
title_fullStr The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes
title_full_unstemmed The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes
title_short The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes
title_sort radioprotective effect of resveratrol against genotoxicity induced by γ-irradiation in mice blood lymphocytes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439647/
https://www.ncbi.nlm.nih.gov/pubmed/28566983
http://dx.doi.org/10.1177/1559325817705699
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