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Protein kinase C theta is dispensable for suppression mediated by CD25(+)CD4(+) regulatory T cells

The activation of conventional T cells upon T cell receptor stimulation critically depends on protein kinase C theta (PKCθ). However, its role in regulatory T (Treg) cell function has yet to be fully elucidated. Using siRNA or the potent and PKC family-selective pharmacological inhibitor AEB071, we...

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Detalles Bibliográficos
Autores principales:	Siegmund, Kerstin, Thuille, Nikolaus, Wachowicz, Katarzyna, Hermann-Kleiter, Natascha, Baier, Gottfried
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439664/ https://www.ncbi.nlm.nih.gov/pubmed/28531229 http://dx.doi.org/10.1371/journal.pone.0175463

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