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Simvastatin modulates gingival cytokine and MMP production in a rat model of ligature-induced periodontitis

PURPOSE: The aim of this study was to evaluate the effect of simvastatin on the synthesis of cytokines TNF-α and IL-10 and metalloproteinase (MMPs) 2 and 9 in a rat model of ligature-induced periodontitis. MATERIALS AND METHODS: Twenty Wistar rats were used, and a cotton ligature was place in a subg...

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Detalles Bibliográficos
Autores principales:	Mouchrek Júnior, José Carlos Elias, Macedo, Cristina Gomes, Abdalla, Henrique Ballassini, Saba, Ana Karina, Teixeira, Lucas Novaes, Mouchrek, Adriana Quinzeiro e Silva, Napimoga, Marcelo Henrique, Clemente-Napimoga, Juliana Trindade, Borges, Alvaro Henrique, Tonetto, Mateus Rodrigues, Pinto, Shelon Cristina Souza, Bandeca, Matheus Coelho, Martinez, Elizabeth Ferreira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439939/ https://www.ncbi.nlm.nih.gov/pubmed/28553143 http://dx.doi.org/10.2147/CCIDE.S134125

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