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Methotrexate carried in lipid core nanoparticles reduces myocardial infarction size and improves cardiac function in rats

PURPOSE: Acute myocardial infarction (MI) is accompanied by myocardial inflammation, fibrosis, and ventricular remodeling that, when excessive or not properly regulated, may lead to heart failure. Previously, lipid core nanoparticles (LDE) used as carriers of the anti-inflammatory drug methotrexate...

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Detalles Bibliográficos
Autores principales:	Maranhão, Raul C, Guido, Maria C, de Lima, Aline D, Tavares, Elaine R, Marques, Alyne F, Tavares de Melo, Marcelo D, Nicolau, Jose C, Salemi, Vera MC, Kalil-Filho, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440040/ https://www.ncbi.nlm.nih.gov/pubmed/28553113 http://dx.doi.org/10.2147/IJN.S129324

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