PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast

PCNA ubiquitylation on lysine 164 is required for DNA damage tolerance. In many organisms PCNA is also ubiquitylated in unchallenged S phase but the significance of this has not been established. Using Schizosaccharomyces pombe, we demonstrate that lysine 164 ubiquitylation of PCNA contributes to ef...

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Detalles Bibliográficos
Autores principales: Daigaku, Yasukazu, Etheridge, Thomas J., Nakazawa, Yuka, Nakayama, Mayumi, Watson, Adam T., Miyabe, Izumi, Ogi, Tomoo, Osborne, Mark A., Carr, Antony M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440044/
https://www.ncbi.nlm.nih.gov/pubmed/28481910
http://dx.doi.org/10.1371/journal.pgen.1006789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440044/
https://www.ncbi.nlm.nih.gov/pubmed/28481910
http://dx.doi.org/10.1371/journal.pgen.1006789

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