Comparison in anesthetic effects of propofol among patients with different ABO blood groups

Our study was aimed to investigate anesthetic effects of propofol in patients with different blood groups. A total of 72 participants were enrolled from patients arranged for surgeries of cholecystectomy, tonsillectomy, and spinal operation. Each blood group (A, B, AB, and O) contained 18 participants. Mean arterial pressure (MAP), heart rate (HR), and bispectral index (BIS) were assayed with Philips monitor. These indexes were observed before propofol anesthesia (T(0)), and then were recorded when concentration of propofol was 1 μg/mL (T(1)), 2 μg/mL (T(2)), 3 μg/mL (T(3)), and 4 μg/mL (T(4)). The differences in MAP, HR, and BIS at T(0) among groups were compared with the χ(2) test. Multiple comparisons were adopted to calculate the differences in MAP, HR, and BIS between groups at T(1), T(2), T(3), and T(4). No significant differences in age, sex, and weight of all groups were found (P > .05). Before propofol anesthesia (T(0)), all the participants exhibited no differences in MAP, HR, and BIS (P > .05). Subsequently, we found obvious differences in ΔMAP, ΔHR, and ΔBIS between groups. The patients in the B blood group showed highest ΔMAP and ΔHR at each time point (P < .05 for both). As for ΔBIS, patients in A blood group exhibited highest value at T(3) and T(4) (P < .05). The blood group remarkably affects the anesthetic effects of propofol.