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The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord
Descending connections from brainstem nuclei are known to exert powerful control of spinal nociception and pain behaviours in adult mammals. Here we present evidence that descending serotonergic fibres not only inhibit nociceptive activity, but also facilitate non-noxious tactile activity in the hea...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440407/ https://www.ncbi.nlm.nih.gov/pubmed/28533557 http://dx.doi.org/10.1038/s41598-017-02509-2 |
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author | Schwaller, F. Kanellopoulos, A. H. Fitzgerald, M. |
author_facet | Schwaller, F. Kanellopoulos, A. H. Fitzgerald, M. |
author_sort | Schwaller, F. |
collection | PubMed |
description | Descending connections from brainstem nuclei are known to exert powerful control of spinal nociception and pain behaviours in adult mammals. Here we present evidence that descending serotonergic fibres not only inhibit nociceptive activity, but also facilitate non-noxious tactile activity in the healthy adult rat spinal dorsal horn via activation of spinal 5-HT(3) receptors (5-HT(3)Rs). We further show that this differential serotonergic control in the adult emerges from a non-modality selective system in young rats. Serotonergic fibres exert background 5-HT(3)R mediated facilitation of both tactile and nociceptive spinal activity in the first three postnatal weeks. Thus, differential descending serotonergic control of spinal touch and pain processing emerges in late postnatal life to allow flexible and context-dependent brain control of somatosensation. |
format | Online Article Text |
id | pubmed-5440407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54404072017-05-25 The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord Schwaller, F. Kanellopoulos, A. H. Fitzgerald, M. Sci Rep Article Descending connections from brainstem nuclei are known to exert powerful control of spinal nociception and pain behaviours in adult mammals. Here we present evidence that descending serotonergic fibres not only inhibit nociceptive activity, but also facilitate non-noxious tactile activity in the healthy adult rat spinal dorsal horn via activation of spinal 5-HT(3) receptors (5-HT(3)Rs). We further show that this differential serotonergic control in the adult emerges from a non-modality selective system in young rats. Serotonergic fibres exert background 5-HT(3)R mediated facilitation of both tactile and nociceptive spinal activity in the first three postnatal weeks. Thus, differential descending serotonergic control of spinal touch and pain processing emerges in late postnatal life to allow flexible and context-dependent brain control of somatosensation. Nature Publishing Group UK 2017-05-22 /pmc/articles/PMC5440407/ /pubmed/28533557 http://dx.doi.org/10.1038/s41598-017-02509-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Schwaller, F. Kanellopoulos, A. H. Fitzgerald, M. The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord |
title | The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord |
title_full | The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord |
title_fullStr | The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord |
title_full_unstemmed | The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord |
title_short | The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord |
title_sort | developmental emergence of differential brainstem serotonergic control of the sensory spinal cord |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440407/ https://www.ncbi.nlm.nih.gov/pubmed/28533557 http://dx.doi.org/10.1038/s41598-017-02509-2 |
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