Cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers

This letter is meant to make scientists aware of the proper application of transmission electron microscopy (TEM) for the assessment of polymeric self-assemblies. Cryogenic (cryo)-TEM should be the method of choice. Here, we show the difference in morphologies observed in the same sample when using...

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Detalles Bibliográficos
Autores principales: Laan, Adrianus C., Denkova, Antonia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Letter to Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440420/
https://www.ncbi.nlm.nih.gov/pubmed/28534134
http://dx.doi.org/10.1186/s13550-017-0290-3
Descripción
Sumario:This letter is meant to make scientists aware of the proper application of transmission electron microscopy (TEM) for the assessment of polymeric self-assemblies. Cryogenic (cryo)-TEM should be the method of choice. Here, we show the difference in morphologies observed in the same sample when using cryo-TEM and when using TEM with drying, demonstrating the importance of choosing the proper method.

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