Cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers

This letter is meant to make scientists aware of the proper application of transmission electron microscopy (TEM) for the assessment of polymeric self-assemblies. Cryogenic (cryo)-TEM should be the method of choice. Here, we show the difference in morphologies observed in the same sample when using...

Descripción completa

Detalles Bibliográficos
Autores principales: Laan, Adrianus C., Denkova, Antonia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Letter to Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440420/
https://www.ncbi.nlm.nih.gov/pubmed/28534134
http://dx.doi.org/10.1186/s13550-017-0290-3
_version_ 1783238050869936128
author Laan, Adrianus C.
Denkova, Antonia G.
author_facet Laan, Adrianus C.
Denkova, Antonia G.
author_sort Laan, Adrianus C.
collection PubMed
description This letter is meant to make scientists aware of the proper application of transmission electron microscopy (TEM) for the assessment of polymeric self-assemblies. Cryogenic (cryo)-TEM should be the method of choice. Here, we show the difference in morphologies observed in the same sample when using cryo-TEM and when using TEM with drying, demonstrating the importance of choosing the proper method.
format Online
Article
Text
id pubmed-5440420
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-54404202017-06-22 Cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers Laan, Adrianus C. Denkova, Antonia G. EJNMMI Res Letter to Editor This letter is meant to make scientists aware of the proper application of transmission electron microscopy (TEM) for the assessment of polymeric self-assemblies. Cryogenic (cryo)-TEM should be the method of choice. Here, we show the difference in morphologies observed in the same sample when using cryo-TEM and when using TEM with drying, demonstrating the importance of choosing the proper method. Springer Berlin Heidelberg 2017-05-22 /pmc/articles/PMC5440420/ /pubmed/28534134 http://dx.doi.org/10.1186/s13550-017-0290-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Letter to Editor
Laan, Adrianus C.
Denkova, Antonia G.
Cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers
title Cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers
title_full Cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers
title_fullStr Cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers
title_full_unstemmed Cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers
title_short Cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers
title_sort cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers
topic Letter to Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440420/
https://www.ncbi.nlm.nih.gov/pubmed/28534134
http://dx.doi.org/10.1186/s13550-017-0290-3
work_keys_str_mv AT laanadrianusc cryogenictransmissionelectronmicroscopythetechniqueofchoiceforthecharacterizationofpolymericnanocarriers
AT denkovaantoniag cryogenictransmissionelectronmicroscopythetechniqueofchoiceforthecharacterizationofpolymericnanocarriers

Ejemplares similares