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Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections
Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to subvert the host response for their own benefit, leading to successful colonization and invasion. Pathogenic bacteria produce multiple compounds that generate favorable conditions to their survival and growth during...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440457/ https://www.ncbi.nlm.nih.gov/pubmed/28589102 http://dx.doi.org/10.3389/fcimb.2017.00208 |
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author | El-Aouar Filho, Rachid A. Nicolas, Aurélie De Paula Castro, Thiago L. Deplanche, Martine De Carvalho Azevedo, Vasco A. Goossens, Pierre L. Taieb, Frédéric Lina, Gerard Le Loir, Yves Berkova, Nadia |
author_facet | El-Aouar Filho, Rachid A. Nicolas, Aurélie De Paula Castro, Thiago L. Deplanche, Martine De Carvalho Azevedo, Vasco A. Goossens, Pierre L. Taieb, Frédéric Lina, Gerard Le Loir, Yves Berkova, Nadia |
author_sort | El-Aouar Filho, Rachid A. |
collection | PubMed |
description | Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to subvert the host response for their own benefit, leading to successful colonization and invasion. Pathogenic bacteria produce multiple compounds that generate favorable conditions to their survival and growth during infection in eukaryotic hosts. Many bacterial toxins can alter the cell cycle progression of host cells, impairing essential cellular functions and impeding host cell division. This review summarizes current knowledge regarding cyclomodulins, a heterogeneous family of bacterial effectors that induce eukaryotic cell cycle alterations. We discuss the mechanisms of actions of cyclomodulins according to their biochemical properties, providing examples of various cyclomodulins such as cycle inhibiting factor, γ-glutamyltranspeptidase, cytolethal distending toxins, shiga toxin, subtilase toxin, anthrax toxin, cholera toxin, adenylate cyclase toxins, vacuolating cytotoxin, cytotoxic necrotizing factor, Panton-Valentine leukocidin, phenol soluble modulins, and mycolactone. Special attention is paid to the benefit provided by cyclomodulins to bacteria during colonization of the host. |
format | Online Article Text |
id | pubmed-5440457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54404572017-06-06 Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections El-Aouar Filho, Rachid A. Nicolas, Aurélie De Paula Castro, Thiago L. Deplanche, Martine De Carvalho Azevedo, Vasco A. Goossens, Pierre L. Taieb, Frédéric Lina, Gerard Le Loir, Yves Berkova, Nadia Front Cell Infect Microbiol Microbiology Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to subvert the host response for their own benefit, leading to successful colonization and invasion. Pathogenic bacteria produce multiple compounds that generate favorable conditions to their survival and growth during infection in eukaryotic hosts. Many bacterial toxins can alter the cell cycle progression of host cells, impairing essential cellular functions and impeding host cell division. This review summarizes current knowledge regarding cyclomodulins, a heterogeneous family of bacterial effectors that induce eukaryotic cell cycle alterations. We discuss the mechanisms of actions of cyclomodulins according to their biochemical properties, providing examples of various cyclomodulins such as cycle inhibiting factor, γ-glutamyltranspeptidase, cytolethal distending toxins, shiga toxin, subtilase toxin, anthrax toxin, cholera toxin, adenylate cyclase toxins, vacuolating cytotoxin, cytotoxic necrotizing factor, Panton-Valentine leukocidin, phenol soluble modulins, and mycolactone. Special attention is paid to the benefit provided by cyclomodulins to bacteria during colonization of the host. Frontiers Media S.A. 2017-05-23 /pmc/articles/PMC5440457/ /pubmed/28589102 http://dx.doi.org/10.3389/fcimb.2017.00208 Text en Copyright © 2017 El-Aouar Filho, Nicolas, De Paula Castro, Deplanche, De Carvalho Azevedo, Goossens, Taieb, Lina, Le Loir and Berkova. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology El-Aouar Filho, Rachid A. Nicolas, Aurélie De Paula Castro, Thiago L. Deplanche, Martine De Carvalho Azevedo, Vasco A. Goossens, Pierre L. Taieb, Frédéric Lina, Gerard Le Loir, Yves Berkova, Nadia Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections |
title | Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections |
title_full | Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections |
title_fullStr | Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections |
title_full_unstemmed | Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections |
title_short | Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections |
title_sort | heterogeneous family of cyclomodulins: smart weapons that allow bacteria to hijack the eukaryotic cell cycle and promote infections |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440457/ https://www.ncbi.nlm.nih.gov/pubmed/28589102 http://dx.doi.org/10.3389/fcimb.2017.00208 |
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