Molecular and cellular insights into Zika virus-related neuropathies

Zika virus (ZIKV), a relatively elusive Aedes mosquito-transmitted flavivirus, had been brought into spotlight until recent widespread outbreaks accompanied by unexpectedly severe clinical neuropathies, including fetal microcephaly and Guillain–Barré syndrome (GBS) in the adult. In this review, we f...

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Detalles Bibliográficos
Autores principales: Zhou, Kai, Wang, Long, Yu, Di, Huang, Hesuyuan, Ji, Hong, Mo, Xuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440482/
https://www.ncbi.nlm.nih.gov/pubmed/28127671
http://dx.doi.org/10.1007/s13365-017-0514-3
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author Zhou, Kai
Wang, Long
Yu, Di
Huang, Hesuyuan
Ji, Hong
Mo, Xuming
author_facet Zhou, Kai
Wang, Long
Yu, Di
Huang, Hesuyuan
Ji, Hong
Mo, Xuming
author_sort Zhou, Kai
collection PubMed
description Zika virus (ZIKV), a relatively elusive Aedes mosquito-transmitted flavivirus, had been brought into spotlight until recent widespread outbreaks accompanied by unexpectedly severe clinical neuropathies, including fetal microcephaly and Guillain–Barré syndrome (GBS) in the adult. In this review, we focus on the underlying cellular and molecular mechanisms by which vertically transmitted microorganisms reach the fetus and trigger neuropathies.
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spelling pubmed-54404822017-06-08 Molecular and cellular insights into Zika virus-related neuropathies Zhou, Kai Wang, Long Yu, Di Huang, Hesuyuan Ji, Hong Mo, Xuming J Neurovirol Review Zika virus (ZIKV), a relatively elusive Aedes mosquito-transmitted flavivirus, had been brought into spotlight until recent widespread outbreaks accompanied by unexpectedly severe clinical neuropathies, including fetal microcephaly and Guillain–Barré syndrome (GBS) in the adult. In this review, we focus on the underlying cellular and molecular mechanisms by which vertically transmitted microorganisms reach the fetus and trigger neuropathies. Springer International Publishing 2017-01-26 2017 /pmc/articles/PMC5440482/ /pubmed/28127671 http://dx.doi.org/10.1007/s13365-017-0514-3 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Zhou, Kai
Wang, Long
Yu, Di
Huang, Hesuyuan
Ji, Hong
Mo, Xuming
Molecular and cellular insights into Zika virus-related neuropathies
title Molecular and cellular insights into Zika virus-related neuropathies
title_full Molecular and cellular insights into Zika virus-related neuropathies
title_fullStr Molecular and cellular insights into Zika virus-related neuropathies
title_full_unstemmed Molecular and cellular insights into Zika virus-related neuropathies
title_short Molecular and cellular insights into Zika virus-related neuropathies
title_sort molecular and cellular insights into zika virus-related neuropathies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440482/
https://www.ncbi.nlm.nih.gov/pubmed/28127671
http://dx.doi.org/10.1007/s13365-017-0514-3
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