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Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission

The role of infection with Mycoplasma hominis following cardiothoracic organ transplantation and its source of transmission have not been well-defined. Here, we identify and describe infection with M. hominis in patients following cardiothoracic organ transplantation after reviewing all cardiothorac...

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Autores principales: Sampath, Rahul, Patel, Robin, Cunningham, Scott A., Arif, Sana, Daly, Richard C., Badley, Andrew D., Wylam, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440619/
https://www.ncbi.nlm.nih.gov/pubmed/28438507
http://dx.doi.org/10.1016/j.ebiom.2017.04.026
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author Sampath, Rahul
Patel, Robin
Cunningham, Scott A.
Arif, Sana
Daly, Richard C.
Badley, Andrew D.
Wylam, Mark E.
author_facet Sampath, Rahul
Patel, Robin
Cunningham, Scott A.
Arif, Sana
Daly, Richard C.
Badley, Andrew D.
Wylam, Mark E.
author_sort Sampath, Rahul
collection PubMed
description The role of infection with Mycoplasma hominis following cardiothoracic organ transplantation and its source of transmission have not been well-defined. Here, we identify and describe infection with M. hominis in patients following cardiothoracic organ transplantation after reviewing all cardiothoracic transplantations performed at our center between 1998 and July 2015. We found seven previously unreported cases of M. hominis culture positive infection all of whom presented with pleuritis, surgical site infection, and/or mediastinitis. PCR was used to establish the diagnosis in four cases. In two instances, paired single lung transplant recipients manifested infection, and in one of these pairs, isolates were indistinguishable by multilocus sequence typing (MLST). To investigate the prevalence of M. hominis in the lower respiratory tract, we tested 178 bronchoalveolar lavage (BAL) fluids collected from immunocompromised subjects for M. hominis by PCR; all were negative. Review of the literature revealed an additional 15 cases of M. hominis in lung transplant recipients, most with similar clinical presentations to our cases. We recommend that M. hominis should be considered in post-cardiothoracic transplant infections presenting with pleuritis, surgical site infection, or mediastinitis. M. hominis PCR may facilitate early diagnosis and prompt therapy. Evaluation for possible donor transmission should be considered.
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spelling pubmed-54406192017-05-30 Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission Sampath, Rahul Patel, Robin Cunningham, Scott A. Arif, Sana Daly, Richard C. Badley, Andrew D. Wylam, Mark E. EBioMedicine Research Paper The role of infection with Mycoplasma hominis following cardiothoracic organ transplantation and its source of transmission have not been well-defined. Here, we identify and describe infection with M. hominis in patients following cardiothoracic organ transplantation after reviewing all cardiothoracic transplantations performed at our center between 1998 and July 2015. We found seven previously unreported cases of M. hominis culture positive infection all of whom presented with pleuritis, surgical site infection, and/or mediastinitis. PCR was used to establish the diagnosis in four cases. In two instances, paired single lung transplant recipients manifested infection, and in one of these pairs, isolates were indistinguishable by multilocus sequence typing (MLST). To investigate the prevalence of M. hominis in the lower respiratory tract, we tested 178 bronchoalveolar lavage (BAL) fluids collected from immunocompromised subjects for M. hominis by PCR; all were negative. Review of the literature revealed an additional 15 cases of M. hominis in lung transplant recipients, most with similar clinical presentations to our cases. We recommend that M. hominis should be considered in post-cardiothoracic transplant infections presenting with pleuritis, surgical site infection, or mediastinitis. M. hominis PCR may facilitate early diagnosis and prompt therapy. Evaluation for possible donor transmission should be considered. Elsevier 2017-04-19 /pmc/articles/PMC5440619/ /pubmed/28438507 http://dx.doi.org/10.1016/j.ebiom.2017.04.026 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Sampath, Rahul
Patel, Robin
Cunningham, Scott A.
Arif, Sana
Daly, Richard C.
Badley, Andrew D.
Wylam, Mark E.
Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission
title Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission
title_full Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission
title_fullStr Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission
title_full_unstemmed Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission
title_short Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission
title_sort cardiothoracic transplant recipient mycoplasma hominis: an uncommon infection with probable donor transmission
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440619/
https://www.ncbi.nlm.nih.gov/pubmed/28438507
http://dx.doi.org/10.1016/j.ebiom.2017.04.026
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