Diacylglycerol Kinase ζ Limits Cytokine-dependent Expansion of CD8(+) T Cells with Broad Antitumor Capacity

Interleukin-2 and -15 drive expansion/differentiation of cytotoxic CD8(+) T cells that eliminate targets via antigen-independent killing. This property is clinically relevant for the improvement of T cell-based antitumor therapies. Diacylglycerol kinase α and ζ (DGKα/ζ) metabolize the diacylglycerol...

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Detalles Bibliográficos
Autores principales: Andrada, Elena, Liébana, Rosa, Merida, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440620/
https://www.ncbi.nlm.nih.gov/pubmed/28438506
http://dx.doi.org/10.1016/j.ebiom.2017.04.024

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