Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo

The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manner to the 3′ untranslated regions of many proinflammatory mRNAs and recruits complexes of nucleases to promote rapid mRNA turnover. Mice lacking TTP develop a severe, spontaneous inflammatory syndrome characterized...

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Detalles Bibliográficos
Autores principales: O'Neil, John D., Ross, Ewan A., Ridley, Michael L., Ding, Qize, Tang, Tina, Rosner, Dalya R., Crowley, Thomas, Malhi, Deepak, Dean, Jonathan L., Smallie, Tim, Buckley, Christopher D., Clark, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440651/
https://www.ncbi.nlm.nih.gov/pubmed/28265004
http://dx.doi.org/10.1128/MCB.00536-16

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