CircRNA: functions and properties of a novel potential biomarker for cancer

Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generation and function are not fully clear, recent research has shown that circular RNAs may functi...

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Detalles Bibliográficos
Autores principales: Meng, Shujuan, Zhou, Hecheng, Feng, Ziyang, Xu, Zihao, Tang, Ying, Li, Peiyao, Wu, Minghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440908/
https://www.ncbi.nlm.nih.gov/pubmed/28535767
http://dx.doi.org/10.1186/s12943-017-0663-2
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author Meng, Shujuan
Zhou, Hecheng
Feng, Ziyang
Xu, Zihao
Tang, Ying
Li, Peiyao
Wu, Minghua
author_facet Meng, Shujuan
Zhou, Hecheng
Feng, Ziyang
Xu, Zihao
Tang, Ying
Li, Peiyao
Wu, Minghua
author_sort Meng, Shujuan
collection PubMed
description Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generation and function are not fully clear, recent research has shown that circular RNAs may function as potential molecular markers for disease diagnosis and treatment and play an important role in the initiation and progression of human diseases, especially in tumours. This review summarizes some information about categories, biogenesis, functions at the molecular level, properties of circular RNAs and the possibility of circular RNAs as biomarkers in cancers.
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spelling pubmed-54409082017-05-24 CircRNA: functions and properties of a novel potential biomarker for cancer Meng, Shujuan Zhou, Hecheng Feng, Ziyang Xu, Zihao Tang, Ying Li, Peiyao Wu, Minghua Mol Cancer Review Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generation and function are not fully clear, recent research has shown that circular RNAs may function as potential molecular markers for disease diagnosis and treatment and play an important role in the initiation and progression of human diseases, especially in tumours. This review summarizes some information about categories, biogenesis, functions at the molecular level, properties of circular RNAs and the possibility of circular RNAs as biomarkers in cancers. BioMed Central 2017-05-23 /pmc/articles/PMC5440908/ /pubmed/28535767 http://dx.doi.org/10.1186/s12943-017-0663-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Meng, Shujuan
Zhou, Hecheng
Feng, Ziyang
Xu, Zihao
Tang, Ying
Li, Peiyao
Wu, Minghua
CircRNA: functions and properties of a novel potential biomarker for cancer
title CircRNA: functions and properties of a novel potential biomarker for cancer
title_full CircRNA: functions and properties of a novel potential biomarker for cancer
title_fullStr CircRNA: functions and properties of a novel potential biomarker for cancer
title_full_unstemmed CircRNA: functions and properties of a novel potential biomarker for cancer
title_short CircRNA: functions and properties of a novel potential biomarker for cancer
title_sort circrna: functions and properties of a novel potential biomarker for cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440908/
https://www.ncbi.nlm.nih.gov/pubmed/28535767
http://dx.doi.org/10.1186/s12943-017-0663-2
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