Cargando…
The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discuss...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440915/ https://www.ncbi.nlm.nih.gov/pubmed/28532423 http://dx.doi.org/10.1186/s12967-017-1218-4 |
_version_ | 1783238156465733632 |
---|---|
author | Ren, Ning Atyah, Manar Chen, Wan-Yong Zhou, Chen-Hao |
author_facet | Ren, Ning Atyah, Manar Chen, Wan-Yong Zhou, Chen-Hao |
author_sort | Ren, Ning |
collection | PubMed |
description | Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discusses, from both a genetic and epigenetic point of view, the current detection methods of different agents’ genotoxicity, along with their basic and clinical relation to human cancer, chemotherapy, germ cells and stem cells. |
format | Online Article Text |
id | pubmed-5440915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54409152017-05-25 The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications Ren, Ning Atyah, Manar Chen, Wan-Yong Zhou, Chen-Hao J Transl Med Review Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discusses, from both a genetic and epigenetic point of view, the current detection methods of different agents’ genotoxicity, along with their basic and clinical relation to human cancer, chemotherapy, germ cells and stem cells. BioMed Central 2017-05-22 /pmc/articles/PMC5440915/ /pubmed/28532423 http://dx.doi.org/10.1186/s12967-017-1218-4 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Ren, Ning Atyah, Manar Chen, Wan-Yong Zhou, Chen-Hao The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications |
title | The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications |
title_full | The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications |
title_fullStr | The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications |
title_full_unstemmed | The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications |
title_short | The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications |
title_sort | various aspects of genetic and epigenetic toxicology: testing methods and clinical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440915/ https://www.ncbi.nlm.nih.gov/pubmed/28532423 http://dx.doi.org/10.1186/s12967-017-1218-4 |
work_keys_str_mv | AT renning thevariousaspectsofgeneticandepigenetictoxicologytestingmethodsandclinicalapplications AT atyahmanar thevariousaspectsofgeneticandepigenetictoxicologytestingmethodsandclinicalapplications AT chenwanyong thevariousaspectsofgeneticandepigenetictoxicologytestingmethodsandclinicalapplications AT zhouchenhao thevariousaspectsofgeneticandepigenetictoxicologytestingmethodsandclinicalapplications AT renning variousaspectsofgeneticandepigenetictoxicologytestingmethodsandclinicalapplications AT atyahmanar variousaspectsofgeneticandepigenetictoxicologytestingmethodsandclinicalapplications AT chenwanyong variousaspectsofgeneticandepigenetictoxicologytestingmethodsandclinicalapplications AT zhouchenhao variousaspectsofgeneticandepigenetictoxicologytestingmethodsandclinicalapplications |