The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications

Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discuss...

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Detalles Bibliográficos
Autores principales: Ren, Ning, Atyah, Manar, Chen, Wan-Yong, Zhou, Chen-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440915/
https://www.ncbi.nlm.nih.gov/pubmed/28532423
http://dx.doi.org/10.1186/s12967-017-1218-4
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author Ren, Ning
Atyah, Manar
Chen, Wan-Yong
Zhou, Chen-Hao
author_facet Ren, Ning
Atyah, Manar
Chen, Wan-Yong
Zhou, Chen-Hao
author_sort Ren, Ning
collection PubMed
description Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discusses, from both a genetic and epigenetic point of view, the current detection methods of different agents’ genotoxicity, along with their basic and clinical relation to human cancer, chemotherapy, germ cells and stem cells.
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spelling pubmed-54409152017-05-25 The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications Ren, Ning Atyah, Manar Chen, Wan-Yong Zhou, Chen-Hao J Transl Med Review Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discusses, from both a genetic and epigenetic point of view, the current detection methods of different agents’ genotoxicity, along with their basic and clinical relation to human cancer, chemotherapy, germ cells and stem cells. BioMed Central 2017-05-22 /pmc/articles/PMC5440915/ /pubmed/28532423 http://dx.doi.org/10.1186/s12967-017-1218-4 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Ren, Ning
Atyah, Manar
Chen, Wan-Yong
Zhou, Chen-Hao
The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
title The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
title_full The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
title_fullStr The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
title_full_unstemmed The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
title_short The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
title_sort various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440915/
https://www.ncbi.nlm.nih.gov/pubmed/28532423
http://dx.doi.org/10.1186/s12967-017-1218-4
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