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Emerging roles of chromatin in the maintenance of genome organization and function in plants

Chromatin is not a uniform macromolecular entity; it contains different domains characterized by complex signatures of DNA and histone modifications. Such domains are organized both at a linear scale along the genome and spatially within the nucleus. We discuss recent discoveries regarding mechanism...

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Detalles Bibliográficos
Autores principales: Vergara, Zaida, Gutierrez, Crisanto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440935/
https://www.ncbi.nlm.nih.gov/pubmed/28535770
http://dx.doi.org/10.1186/s13059-017-1236-9
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author Vergara, Zaida
Gutierrez, Crisanto
author_facet Vergara, Zaida
Gutierrez, Crisanto
author_sort Vergara, Zaida
collection PubMed
description Chromatin is not a uniform macromolecular entity; it contains different domains characterized by complex signatures of DNA and histone modifications. Such domains are organized both at a linear scale along the genome and spatially within the nucleus. We discuss recent discoveries regarding mechanisms that establish boundaries between chromatin states and nuclear territories. Chromatin organization is crucial for genome replication, transcriptional silencing, and DNA repair and recombination. The replication machinery is relevant for the maintenance of chromatin states, influencing DNA replication origin specification and accessibility. Current studies reinforce the idea of intimate crosstalk between chromatin features and processes involving DNA transactions.
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spelling pubmed-54409352017-05-25 Emerging roles of chromatin in the maintenance of genome organization and function in plants Vergara, Zaida Gutierrez, Crisanto Genome Biol Review Chromatin is not a uniform macromolecular entity; it contains different domains characterized by complex signatures of DNA and histone modifications. Such domains are organized both at a linear scale along the genome and spatially within the nucleus. We discuss recent discoveries regarding mechanisms that establish boundaries between chromatin states and nuclear territories. Chromatin organization is crucial for genome replication, transcriptional silencing, and DNA repair and recombination. The replication machinery is relevant for the maintenance of chromatin states, influencing DNA replication origin specification and accessibility. Current studies reinforce the idea of intimate crosstalk between chromatin features and processes involving DNA transactions. BioMed Central 2017-05-23 /pmc/articles/PMC5440935/ /pubmed/28535770 http://dx.doi.org/10.1186/s13059-017-1236-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Vergara, Zaida
Gutierrez, Crisanto
Emerging roles of chromatin in the maintenance of genome organization and function in plants
title Emerging roles of chromatin in the maintenance of genome organization and function in plants
title_full Emerging roles of chromatin in the maintenance of genome organization and function in plants
title_fullStr Emerging roles of chromatin in the maintenance of genome organization and function in plants
title_full_unstemmed Emerging roles of chromatin in the maintenance of genome organization and function in plants
title_short Emerging roles of chromatin in the maintenance of genome organization and function in plants
title_sort emerging roles of chromatin in the maintenance of genome organization and function in plants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440935/
https://www.ncbi.nlm.nih.gov/pubmed/28535770
http://dx.doi.org/10.1186/s13059-017-1236-9
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