Improving the production of 22-hydroxy-23,24-bisnorchol-4-ene-3-one from sterols in Mycobacterium neoaurum by increasing cell permeability and modifying multiple genes

BACKGROUND: The strategy of modifying the sterol catabolism pathway in mycobacteria has been adopted to produce steroidal pharmaceutical intermediates, such as 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC), which is used to synthesize various steroids in the industry. However, the productivity is...

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Detalles Bibliográficos
Autores principales: Xiong, Liang-Bin, Liu, Hao-Hao, Xu, Li-Qin, Sun, Wan-Ju, Wang, Feng-Qing, Wei, Dong-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440992/
https://www.ncbi.nlm.nih.gov/pubmed/28532497
http://dx.doi.org/10.1186/s12934-017-0705-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440992/
https://www.ncbi.nlm.nih.gov/pubmed/28532497
http://dx.doi.org/10.1186/s12934-017-0705-x

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