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Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (As(4)S(4)). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted using Acidithiobacillus ferrooxidans (A. ferroox...

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Autores principales: Chen, Peng, Xu, Ruixiang, Yan, Lei, Wu, Zhengrong, Wei, Yan, Zhao, Wenbin, Wang, Xin, Xie, Qinjian, Li, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441017/
https://www.ncbi.nlm.nih.gov/pubmed/28532516
http://dx.doi.org/10.1186/s40659-017-0122-y
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author Chen, Peng
Xu, Ruixiang
Yan, Lei
Wu, Zhengrong
Wei, Yan
Zhao, Wenbin
Wang, Xin
Xie, Qinjian
Li, Hongyu
author_facet Chen, Peng
Xu, Ruixiang
Yan, Lei
Wu, Zhengrong
Wei, Yan
Zhao, Wenbin
Wang, Xin
Xie, Qinjian
Li, Hongyu
author_sort Chen, Peng
collection PubMed
description Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (As(4)S(4)). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted using Acidithiobacillus ferrooxidans (A. ferrooxidans). Bioleaching, a new technology to greatly improve the use rate of arsenic extraction from realgar using bacteria, is a novel methodology that addressed a limitation of the traditional method for realgar preparation. The present systematic review reports on the research progress in realgar bioleaching and its antitumor mechanism as an anticancer agent. A total of 93 research articles that report on the biological activity of extracts from realgar using bacteria and its preparation were presented in this review. The realgar bioleaching solution (RBS) works by inducing apoptosis when it is used to treat tumor cells in vitro and in vivo. When it is used to treat animal model organisms in vivo, such as mice and Caenorhabditis elegans, tumor tissues grew more slowly, with mass necrosis. Meanwhile, the agent also showed obvious inhibition of tumor cell growth. Bioleaching technology greatly improves the utilization of realgar and is a novel methodology to improve the traditional method.
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spelling pubmed-54410172017-05-24 Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent Chen, Peng Xu, Ruixiang Yan, Lei Wu, Zhengrong Wei, Yan Zhao, Wenbin Wang, Xin Xie, Qinjian Li, Hongyu Biol Res Review Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (As(4)S(4)). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted using Acidithiobacillus ferrooxidans (A. ferrooxidans). Bioleaching, a new technology to greatly improve the use rate of arsenic extraction from realgar using bacteria, is a novel methodology that addressed a limitation of the traditional method for realgar preparation. The present systematic review reports on the research progress in realgar bioleaching and its antitumor mechanism as an anticancer agent. A total of 93 research articles that report on the biological activity of extracts from realgar using bacteria and its preparation were presented in this review. The realgar bioleaching solution (RBS) works by inducing apoptosis when it is used to treat tumor cells in vitro and in vivo. When it is used to treat animal model organisms in vivo, such as mice and Caenorhabditis elegans, tumor tissues grew more slowly, with mass necrosis. Meanwhile, the agent also showed obvious inhibition of tumor cell growth. Bioleaching technology greatly improves the utilization of realgar and is a novel methodology to improve the traditional method. BioMed Central 2017-05-22 /pmc/articles/PMC5441017/ /pubmed/28532516 http://dx.doi.org/10.1186/s40659-017-0122-y Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Chen, Peng
Xu, Ruixiang
Yan, Lei
Wu, Zhengrong
Wei, Yan
Zhao, Wenbin
Wang, Xin
Xie, Qinjian
Li, Hongyu
Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title_full Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title_fullStr Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title_full_unstemmed Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title_short Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
title_sort properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441017/
https://www.ncbi.nlm.nih.gov/pubmed/28532516
http://dx.doi.org/10.1186/s40659-017-0122-y
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